Toward Light-Controlled Supramolecular Peptide Dimerization
| Autor: | Rita J. Fernandes, Artur J. Moro, André Seco, Patricia Remón, Nuno Basílio, Uwe Pischel, Ana S. Ferreira |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Bridged-Ring Compounds Light 010405 organic chemistry Organic Chemistry Supramolecular chemistry Imidazoles Peptide Tripeptide 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences Peptides and Proteins chemistry Receptors 23 Química Irradiation Peptides Dimerization |
| DOI: | 10.1021/acs.joc.1c00464 |
| Popis: | The selective photodeprotection of the NVoc-modified FGG tripeptide yields the transformation of its 1:1 receptor−ligand complex with cucurbit[8]uril into a homoternary FGG2@CB8 assembly. The resulting lightinduced dimerization of the model peptide provides a tool for the implementation of stimuli-responsive supramolecular chemistry in biologically relevant contexts. The work was supported by the Associate Laboratory for Green ChemistryLAQV (UIDB/50006/2020) and by the Applied Molecular Biosciences UnitUCIBIO (UIDB/ 04378/2020), both financed by FCT. FCT/MCTES is also acknowledged for supporting the National Portuguese NMR Network (ROTEIRO/0031/2013-PINFRA/22161/2016, cofinanced by FEDER through COMPETE 2020, POCI, PORL, and FCT through PIDDAC) and for the grants PTDC/QUICOL/32351/2017, PTDC/QUI-QFI/30951/2017, and CEECIND/00466/2017 (N.B.). U.P. thanks the Spanish Ministry of Science, Innovation, and Universities (CTQ2017-89832-P). We are grateful to Dr. J.P. Da Silva for the mass spectrometry data (equipment financed by CRESC Algarve 2020 and COMPETE 2020; project EMBRC.PT ALG-01-0145-FEDER022121). Funding for open access charge: Universidad de Huelva / CBUA |
| Databáze: | OpenAIRE |
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