Abnormal auditory and language pathways in children with 16p11.2 deletion
| Autor: | Emily S. Kuschner, Elliott H. Sherr, Randall Buckner, Jeffrey I. Berman, Darina Chudnovskaya, Wendy K. Chung, Srikantan S. Nagarajan, John E. Spiro, Timothy P.L. Roberts, Lisa Blaskey, Pratik Mukherjee |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Auditory Pathways Autism Chromosome Disorders 16p11.2 deletion lcsh:RC346-429 0302 clinical medicine Arcuate fasciculus FA fractional anisotropy Child Language Diffusion MR 0303 health sciences Brain Regular Article Cognition White Matter RD radial diffusivity medicine.anatomical_structure Neurology Autism spectrum disorder Auditory system lcsh:R858-859.7 Female Chromosome Deletion Psychology AD axial diffusivity ASD autism spectrum disorder Adolescent CNV copy number variation Cognitive Neuroscience GFA generalized fractional anisotropy lcsh:Computer applications to medicine. Medical informatics White matter 03 medical and health sciences Intellectual Disability medicine Humans Radiology Nuclear Medicine and imaging Autistic Disorder CELF clinical evaluation of language fundamentals lcsh:Neurology. Diseases of the nervous system 030304 developmental biology MD mean diffusivity HARDI high angular resolution diffusion imaging medicine.disease Diffusion Magnetic Resonance Imaging DTI diffusion tensor imaging Neurology (clinical) Neuroscience Chromosomes Human Pair 16 030217 neurology & neurosurgery Diffusion MRI Spoken language |
| Zdroj: | Sherr, Elliott; Mukherjee, Pratik; Berman, JI; Chudnovskaya, D; Blaskey, L; Kuschner, E; et al.(2015). Abnormal auditory and language pathways in children with 16p11.2 deletion. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/44p5t5dn NeuroImage: Clinical, Vol 9, Iss C, Pp 50-57 (2015) NeuroImage : Clinical |
| Popis: | Copy number variations at chromosome 16p11.2 contribute to neurodevelopmental disorders, including autism spectrum disorder (ASD). This study seeks to improve our understanding of the biological basis of behavioral phenotypes common in ASD, in particular the prominent and prevalent disruption of spoken language seen in children with the 16p11.2 BP4–BP5 deletion. We examined the auditory and language white matter pathways with diffusion MRI in a cohort of 36 pediatric deletion carriers and 45 age-matched controls. Diffusion MR tractography of the auditory radiations and the arcuate fasciculus was performed to generate tract specific measures of white matter microstructure. In both tracts, deletion carriers exhibited significantly higher diffusivity than that of controls. Cross-sectional diffusion parameters in these tracts changed with age with no group difference in the rate of maturation. Within deletion carriers, the left-hemisphere arcuate fasciculus mean and radial diffusivities were significantly negatively correlated with clinical language ability, but not non-verbal cognitive ability. Diffusion metrics in the right-hemisphere arcuate fasciculus were not predictive of language ability. These results provide insight into the link between the 16p11.2 deletion, abnormal auditory and language pathway structures, and the specific behavioral deficits that may contribute to neurodevelopmental disorders such as ASD. Highlights • We examined auditory and language white matter tracts in children with the 16p11.2 BP4–BP5 deletion. • Diffusivity was enhanced in auditory radiation and arcuate fasciculus. • Arcuate fasciculus microstructure was correlated with language ability in deletion carriers. • There are correlations in the brain structure and behavioral phenotype in the 16p11.2 deletion carriers. |
| Databáze: | OpenAIRE |
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