Patients' Attitudes and Physicians' Perceptions Toward Maintenance Therapy for Advanced Non–Small-cell Lung Cancer: A Multicenter Italian Survey
| Autor: | Antonio Rossi, Simona Carnio, M.V. Pacchiana, Anna Ceribelli, Vieri Scotti, Enrica Capelletto, Domenico Galetta, Diego Cortinovis, Luca Ostacoli, Silvia Novello, Francesco Rosetti, G. Valmadre, Paola Bordi, Olga Martelli, Elisabetta Sara Montagna, Massimo Di Maio, Cesare Gridelli, Alessandro Del Conte, R. Morena, Annamaria Miccianza |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Pulmonary and Respiratory Medicine Cancer Research Pediatrics medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Platinum Compounds Pemetrexed 03 medical and health sciences 0302 clinical medicine Maintenance therapy Quality of life Carcinoma Non-Small-Cell Lung Surveys and Questionnaires Antineoplastic Combined Chemotherapy Protocols Humans Medicine Distress Thermometer 030212 general & internal medicine Lung cancer Aged Aged 80 and over Chemotherapy business.industry Patient Preference Middle Aged Patient Acceptance of Health Care medicine.disease Attitude Italy Oncology 030220 oncology & carcinogenesis Doctor–patient relationship Female Perception Non small cell business medicine.drug |
| Zdroj: | Clinical Lung Cancer. 18:381-387 |
| ISSN: | 1525-7304 |
| DOI: | 10.1016/j.cllc.2016.10.002 |
| Popis: | Introduction Pemetrexed maintenance therapy (MT) after induction with platinum-based chemotherapy has recently become a common treatment strategy for advanced nonsquamous non–small-cell lung cancer (NSCLC). However, the benefits of MT should be weighed with consideration of the patients' perceptions and preferences. The aim of the present study was to evaluate patients' attitudes toward MT and to describe physicians' awareness of their patients' inclinations. Materials and Methods We administered a 12-question anonymous survey and the Distress Thermometer Questionnaire to patients with advanced or recurrent nonsquamous NSCLC. The survey was also distributed to the referring physicians. Results From December 2014 to July 2015, 92 patients and 37 physicians were enrolled. All 92 patients completed the questionnaire at T0 (before starting chemotherapy) and 56.5% also did so at T1 (after completion of induction). The physicians completed the survey only at T0. Most patients had a positive attitude toward MT at both T0 (78.9%) and T1 (86.5%), and 100% of the physicians thought their patients would be in favor of MT. The physicians believed that their patients' attitudes toward MT would decrease proportionally with the reduction in the magnitude of the overall survival increase and expected benefits. The decrease expected by the physicians was much greater than that reported by the patients. This was especially true for an overall survival increase as small as 1 month (51.9% of patients accepting MT vs. 13.5% supposed by physicians) or when the only treatment benefit was radiologic tumor stabilization (69.3% of patients accepting MT vs. 37.8% supposed by physicians). Conclusion NSCLC patients have a generally positive attitude toward MT, which is not directly proportional to the expected benefits and greater than the attitude expected by physicians. |
| Databáze: | OpenAIRE |
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