Comparative aspects of Aroclor� 1254 toxicity in adult cynomolgus and rhesus monkeys: A pilot study

Autor: Jos Mes, Jim Wong, Leander Tryphonas, D.L. Arnold, Z.Z. Zawidzka, Helen Tryphonas, S.M. Charbonneau
Rok vydání: 1986
Předmět:
Zdroj: Archives of Environmental Contamination and Toxicology. 15:159-169
ISSN: 1432-0703
0090-4341
DOI: 10.1007/bf01059965
Popis: Aroclor® 1254 (PCB), at a dose of 280 μg/kg body weight (equivalent to 200 μg/kg/day) was given 5 days per week to groups of cynomolgus and rhesus monkeys. Cynomolgus monkeys were treated for 12 to 13 months and rhesus monkeys for 27 to 28 months. The study compares selected clinical, hematologic, immunologic, and analytical findings in the two species up to the time the cynomolgus were killed (12–13 months) and includes the pathologic findings in the latter (terminal findings in the rhesus are the subject of a separate report). Treated rhesus had enlarged tarsal glands, conjunctivitis, loss of eyelashes, progressive detachment of finger nails, exuberant nail beds, and somewhat depressed hematologie values of the erythron. In contrast, treated cynomolgus had temporary enlargement of the tarsal glands, distortion and temporary loss or lifting of nails with limited exposure of the nail beds, and moderate erythroid depression and vacuolization of early erythroid precursors. Histopathologic findings in the cynomolgus monkeys included mild dilatation of tarsal gland ducts, moderately keratinized finger nail beds, and hepatocellular and biliary duct epithelial cell hypertrophy. Immunologie testing was inconclusive due to large interspecies variability. PCB analysis revealed that during the first 18 weeks of treatment rhesus monkeys accumulated PCB faster than did the cynomolgus. It appears that rhesus monkeys are more susceptible to PCB toxicity than cynomolgus monkeys.
Databáze: OpenAIRE
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