Pyoderma Gangrenosum after Fat Grafting in Alloplastic Breast Reconstruction: An Unusual Outcome
Autor: | Sean J Wallace Md, Randolph Wojcik, Ethan Song, Jaan Peter Naktin, Robert Teixeira, Ahmed Mansour, Marshall G. Miles, Yee Cheng Low |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
Erythema Breast surgery medicine.medical_treatment lcsh:Surgery Case Report 030230 surgery 03 medical and health sciences Wound care 0302 clinical medicine Biopsy medicine Breast Debridement medicine.diagnostic_test business.industry lcsh:RD1-811 medicine.disease Surgery medicine.anatomical_structure 030220 oncology & carcinogenesis Abdomen medicine.symptom Breast reconstruction business Pyoderma gangrenosum |
Zdroj: | Plastic and Reconstructive Surgery Global Open Plastic and Reconstructive Surgery, Global Open, Vol 8, Iss 11, p e3223 (2020) |
ISSN: | 2169-7574 |
Popis: | Summary. Pyoderma gangrenosum (PG) is a rare and painful inflammatory skin disorder that has been recently associated with breast surgery. It is commonly mistaken for postoperative ischemia or wound infection and does not show response to antibiotics or debridement. We describe the first case of post-surgical PG (PSPG) after alloplastic breast reconstruction involving fat grafting. A 47-year-old woman underwent bilateral mastectomy and 2-stage alloplastic breast reconstruction, with fat grafting from the abdomen. Two days post-surgery, she developed bilateral erythema with tender grouped pustules that progressed rapidly into necrotic ulcerations. She did not respond to antibiotics and serial debridement. Subsequent biopsy confirmed a diagnosis of PG. She was started on steroid therapy and responded well. She was discharged on a steroid regimen, local wound care, and eventually a T-cell inhibitor. Over the next 12 months, her wounds healed without surgical intervention. PSPG has been observed in a variety of reconstructive breast surgeries, but never reported in the setting of fat grafting. As PG involves subcutaneous fat, fat grafting may accelerate and exacerbate the course of disease. Treatment for PSPG includes systemic steroid therapy or other immunomodulatory agents (or both). Surgical management remains controversial, as serial debridement and reconstruction have shown to exacerbate and stimulate disease progression. A long-term follow-up is recommended to monitor for wound healing. Delayed diagnosis of PG in breast reconstruction patients can lead to severe morbidity and disfigurement. This is first case of PSPG following fat grafting in the literature. |
Databáze: | OpenAIRE |
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