Organocatalytic Asymmetric α-Sulfenylation of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral 2,2-Disubstituted Indole-3-ones with S- and N-Containing Heteroquaternary Carbon Stereocenter

Autor:	Xiao-Zhong Fu, Fen-Fen Yang, Chun Li, Yuanhu Mao, Meng Zhou, Yong-Long Zhao, Yong-Xi Dong, Yong-Qin Tang, Bin He, Peng-Fei Xu, Yuan-Yong Yang, Xing-Hai Fei
Rok vydání:	2019
Předmět:	Indole test 010405 organic chemistry Organic Chemistry Squaramide chemistry.chemical_element 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis Succinimides Stereocenter chemistry Yield (chemistry) Organic chemistry Carbon
Zdroj:	The Journal of organic chemistry. 84(12)
ISSN:	1520-6904
Popis:	An organocatalytic asymmetric α-sulfenylation of 2-substituted indolin-3-ones with N-(alkylthio or arylthio)succinimides has been developed for the first time using Cinchona-derived squaramide as the catalyst. Various chiral 2,2-disubstituted indole-3-ones with S- and N-containing heteroquaternary carbon stereocenters were obtained with up to 98% yield and 99% ee.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24f4f6b4664b114cc01e0967c865bff3 https://pubmed.ncbi.nlm.nih.gov/31192597 Zobrazit plný text záznamu