Vasopressin plus oxygen vs vasopressin alone in cirrhotic patients with portal-hypertensive gastropathy: Effects on gastric mucosal haemodynamics and oxygenation
| Autor: | Atsushi Toyonaga, Tadashi Iwao, Kazuhiko Oho, Michihiro Sumino, Kyuichi Tanikawa, Masahiro Sato, Hiroyuki Shigemori |
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| Rok vydání: | 1996 |
| Předmět: |
Liver Cirrhosis
Male Vasopressin medicine.medical_specialty Vasopressins Stomach Diseases Hemodynamics Portal hypertensive gastropathy Hyperaemia Double-Blind Method Internal medicine Hypertension Portal Laser-Doppler Flowmetry medicine Humans Aged Oxygen saturation (medicine) Analysis of Variance Hepatology business.industry Oxygen Inhalation Therapy Gastroenterology Oxygenation Middle Aged Hypoxia (medical) medicine.disease Combined Modality Therapy Oxygen Endocrinology Gastric Mucosa Spectrophotometry Female medicine.symptom business Perfusion hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Gastroenterology and Hepatology. 11:216-222 |
| ISSN: | 1440-1746 0815-9319 |
| Popis: | The effects of vasopressin plus oxygen and vasopressin alone on gastric mucosal perfusion and oxygenation were studied using reflectance spectrophotometry and laser Doppler velocimetry in 23 cirrhotic patients with portal-hypertensive gastropathy. The measurements were performed under basal conditions and after double-blinded administration of placebo (n = 7), vasopressin (0.3 U/min; n = 8) or vasopressin (0.3 U/min) plus nasal oxygen (4 L/min; n = 8). No significant effects on gastric mucosal haemodynamics and oxygenation were observed after placebo. In contrast, vasopressin and vasopressin plus oxygen induced a similar reduction in haemoglobin content (-26 +/- 2 and -21 +/- 4%, respectively P < 0.01), and laser Doppler signal (-23 +/- 2 and -22 +/- 2%, respectively, P < 0.01). Although each treatment induced a significant reduction in oxygen saturation (-21 +/- 2 and -7 +/- 1%, respectively P < 0.01), the effect was less pronounced in patients receiving the combination than in those receiving vasopressin alone (P < 0.01). These data suggest that vasopressin and vasopressin plus oxygen reduce gastric mucosal hyperaemia and that the oxygen supplement partially protects against gastric mucosal hypoxia during vasopressin infusion in cirrhotic patients with portal-hypertensive gastropathy. |
| Databáze: | OpenAIRE |
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