Impact of Hemoglobin on Plasma Pro-B-Type Natriuretic Peptide Concentrations in the General Population
| Autor: | Peter Schnohr, Jens P. Goetze, Jan Skov Jensen, Jens F. Rehfeld, Rasmus Mogelvang, Mads Nybo, Marianne Benn |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Heart disease medicine.drug_class Anemia Clinical Biochemistry Population Renal function Gastroenterology Ventricular Function Left Hemoglobins Plasma Reference Values Internal medicine Natriuretic Peptide Brain Natriuretic peptide medicine Humans cardiovascular diseases Protein Precursors education Aged education.field_of_study business.industry Biochemistry (medical) Middle Aged medicine.disease Brain natriuretic peptide Endocrinology Case-Control Studies Heart failure Regression Analysis Female Hemoglobin business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Nybo, M, Benn, M, Mogelvang, R, Jensen, J S, Schnohr, P, Rehfeld, J F & Goetze, J P 2007, ' Impact of hemoglobin on plasma pro-B-type natriuretic peptide concentrations in the general population ', Clinical Chemistry, vol. 53, no. 11, pp. 1921-1927 . https://doi.org/10.1373/clinchem.2007.089391 |
| ISSN: | 1530-8561 0009-9147 |
| Popis: | Background: Age, sex, and renal function contribute to variations in plasma concentrations of B-type natriuretic peptide (BNP) and its molecular precursor (proBNP). Recent studies indicate that anemia may also affect proBNP concentrations in patients with heart failure or stroke. However, the impact of hemoglobin status on proBNP concentrations has not been established in the general population.Methods: In the 4th examination in the Copenhagen City Heart Study, we performed a nested case-control study of 6238 individuals from a Danish general population. Of these, 3497 randomly selected participants also underwent an echocardiographic examination. The population was stratified into groups depending on health and hemoglobin status. Correlations between hemoglobin and proBNP concentrations were examined by simple and multiple regression analyses, adjusted for variables known to influence the proBNP plasma concentration.Results: The mean proBNP concentration was increased 1.7-fold in the group with anemia vs the nonanemic group [mean (SD) 42 (45) pmol/L vs 25 (29) pmol/L, P Conclusions: Because moderate anemia is associated with a 1.7-fold increase in proBNP concentrations, hemoglobin concentrations should be taken into consideration in patients with nonspecific symptoms of heart disease and increased proBNP concentrations. |
| Databáze: | OpenAIRE |
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