Dysregulated healing response participates in the pathophysiology of temporomandibular joint ankylosis
| Autor: | Marcela Hernández, Montserrat Reyes, Luis A. Córdova, Juan E. Cortés, Rubén Soto |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Pathology medicine.medical_specialty Ankylosis Connective tissue Bone healing Bone resorption Bone remodeling 03 medical and health sciences 0302 clinical medicine medicine Humans Child Retrospective Studies Temporomandibular Joint business.industry Ossification Cartilage Mandibular Condyle 030206 dentistry Temporomandibular Joint Disorders medicine.disease Temporomandibular joint medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Female Surgery Oral Surgery medicine.symptom business |
| Zdroj: | Journal of Cranio-Maxillofacial Surgery. 49:592-597 |
| ISSN: | 1010-5182 |
| DOI: | 10.1016/j.jcms.2021.02.014 |
| Popis: | This study aimed to characterize samples from patients diagnosed with TMJ ankylosis, using both clinical and histological data. Both clinical and histological analyses of retrieved tissue samples from patients with primary TMJ ankyloses were performed retrospectively (1980–2012). All patients had been subjected to primary arthroplasty. Our study analyzed connective tissue differentiation, ossification patterns, and bone resorption, using histology and immunohistochemistry. Fifteen case records, with a sex ratio of 4:1 (men:woman) and a median age of 8 years, were collected. Six patient samples reported a previous inflammatory event. Histologically, 15 samples exhibited fibrous tissue. Among these, 13 displayed bone at different stages of maturity (fibrous/bony ankylosis). Eleven samples showed aberrant cartilage, characterized by hypertrophic chondrocyte-like cells at the bone/cartilage interface. Four samples revealed inflammatory infiltrate; in one case, this was organized as a lymphoid follicle. Eleven samples showed bone resorption by attached osteoclasts. Interestingly, non-attached osteoclasts were detected, suggesting locally impaired bone remodeling. An association between the presence of mature/lamellar bone and the presence of osteoclasts was observed (p = 0.03). No association was found between previous history of either trauma or infection and the histological type of ankylosis (p = 0.74). There was no association between the histological presence of inflammation or infection and the type of ankylosis (p = 0.63 and p = 0.87, respectively). Retrieved TMJ ankylosis tissues displayed both aberrant ossification and reduced focal bone resorption, suggesting a dysregulated healing response. |
| Databáze: | OpenAIRE |
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