Cross-Disciplinary Genomics Approaches to Studying Emerging Fungal Infections
| Autor: | Lola Brookes, Jennifer M. G. Shelton, Phillip Jervis, Thomas R. Sewell, Dana Kappel, Pria Ghosh, Emily Skelly, Matthew C. Fisher, Johanna Rhodes, Hannah M. Edwards |
|---|---|
| Přispěvatelé: | Natural Environment Research Council [2006-2012], Wellcome Trust, Natural Environment Research Council (NERC), Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Life Sciences & Biomedicine - Other Topics
0301 basic medicine GEOMYCES-DESTRUCTANS 030106 microbiology VANCOUVER-ISLAND Large population Wildlife Genomics Review Biology Microbiology General Biochemistry Genetics and Molecular Biology MAGNAPORTHE emerging fungal pathogen 03 medical and health sciences Human health BATRACHOCHYTRIUM-DENDROBATIDIS PATHOGEN MYCOSPHAERELLA-GRAMINICOLA Food supply Human medicine lcsh:Science Ecology Evolution Behavior and Systematics GENE-EXPRESSION Science & Technology Cross disciplinary REAL-TIME Paleontology fungal-omics Omics Data science POPULATION GENOMICS cross-disciplinary Biology and Microbiology 030104 developmental biology Health Space and Planetary Science CRYPTOCOCCUS-GATTII lcsh:Q Life Sciences & Biomedicine RESISTANCE |
| Zdroj: | Life, Vol 10, Iss 315, p 315 (2020) Life |
| ISSN: | 2075-1729 |
| Popis: | Emerging fungal pathogens pose a serious, global and growing threat to food supply systems, wild ecosystems, and human health. However, historic chronic underinvestment in their research has resulted in a limited understanding of their epidemiology relative to bacterial and viral pathogens. Therefore, the untargeted nature of genomics and, more widely, -omics approaches is particularly attractive in addressing the threats posed by and illuminating the biology of these pathogens. Typically, research into plant, human and wildlife mycoses have been largely separated, with limited dialogue between disciplines. However, many serious mycoses facing the world today have common traits irrespective of host species, such as plastic genomes; wide host ranges; large population sizes and an ability to persist outside the host. These commonalities mean that -omics approaches that have been productively applied in one sphere and may also provide important insights in others, where these approaches may have historically been underutilised. In this review, we consider the advances made with genomics approaches in the fields of plant pathology, human medicine and wildlife health and the progress made in linking genomes to other -omics datatypes and sets; we identify the current barriers to linking -omics approaches and how these are being underutilised in each field; and we consider how and which -omics methodologies it is most crucial to build capacity for in the near future. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|