Neonatal dexamethasone treatment induces long-lasting changes in T-cell receptor Vβ repertoire in rats
| Autor: | Frank van Bel, Jitske Zijlstra, J.G.M. Bakker, Annemieke Kavelaars, Patrick Joseph Gerardus Hendrikus Kamphuis, Cobi Jacoba Johanna Heijnen |
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| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Receptors Antigen T-Cell alpha-beta T-Lymphocytes T cell Immunology CD4-CD8 Ratio Biology Dexamethasone chemistry.chemical_compound Immune system Pregnancy Corticosterone Internal medicine medicine Animals Immunology and Allergy Cytotoxic T cell Rats Wistar Respiratory distress T-cell receptor Age Factors Rats Endocrinology medicine.anatomical_structure Animals Newborn Neurology chemistry Pregnenolone Female Neurology (clinical) Glucocorticoid medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 112:47-54 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/s0165-5728(00)00406-9 |
| Popis: | Glucocorticoids are frequently administered for the prevention of chronic lung disease in infants with respiratory distress syndrome. However, neonatal treatment may have consequences for immune functioning in the long-term. Here we demonstrate that neonatal glucocorticoid treatment has long-lasting effects on mRNA expression of several Vβ genes within the CD4 and CD8 T cell subset in rats. Changes in the peripheral T cell Vβ repertoire may be a consequence of altered intrathymic selection events in which corticosterone plays an important role. Indeed, here we show that neonatal glucocorticoid treatment affects corticosterone production by thymic epithelial cells during neonatal life. In conclusion, changes in T cell Vβ repertoire after neonatal glucocorticoid treatment may contribute to altered immune reactivity in later life. |
| Databáze: | OpenAIRE |
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