Early motor activity drives spindle bursts in the developing somatosensory cortex
| Autor: | Rustem Khazipov, Anton Sirota, Yehezkel Ben-Ari, Xavier Leinekugel, György Buzsáki, Gregory L. Holmes |
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| Přispěvatelé: | Epilepsie et ischémie cérébrale, Université de la Méditerranée - Aix-Marseille 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Neurosurgery [Boston], Brigham and Women's Hospital [Boston], CMBN, Rutgers, The State University of New Jersey [New Brunswick] (RU), Rutgers University System (Rutgers)-Rutgers University System (Rutgers), Cortex et Epilepsie [Paris], Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Tyzio, Roman, CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC) |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Aging
Patch-Clamp Techniques MESH: Movement Somatosensory system MESH: Animals Newborn MESH: Synapses MESH: Spinal Cord 0302 clinical medicine MESH: Neural Conduction Premovement neuronal activity MESH: Animals MESH: Aging MESH: Receptors GABA-A 0303 health sciences Multidisciplinary Anatomy MESH: Temperature MESH: Motor Activity medicine.anatomical_structure Spinal Cord MESH: Axons MESH: Rats Movement Period (gene) Central nervous system Sensory system MESH: Acclimatization MESH: Psychomotor Performance [SDV.BC]Life Sciences [q-bio]/Cellular Biology Motor Activity Biology MESH: Somatosensory Cortex 03 medical and health sciences MESH: Patch-Clamp Techniques medicine Animals Motor activity MESH: Excitatory Postsynaptic Potentials [SDV.BC] Life Sciences [q-bio]/Cellular Biology 030304 developmental biology MESH: Annelida Excitatory Postsynaptic Potentials Somatosensory Cortex Receptors GABA-A Rats Electrophysiology Animals Newborn Somatosensory evoked potential Synapses Neuroscience Psychomotor Performance 030217 neurology & neurosurgery |
| Zdroj: | Journal of Experimental Biology Journal of Experimental Biology, The Company of Biologists, 2004, 432 (7018), pp.758-61. ⟨10.1038/nature03132⟩ Journal of Experimental Biology, 2004, 432 (7018), pp.758-61. ⟨10.1038/nature03132⟩ |
| ISSN: | 0022-0949 1477-9145 |
| DOI: | 10.1038/nature03132⟩ |
| Popis: | International audience; Sensorimotor coordination emerges early in development. The maturation period is characterized by the establishment of somatotopic cortical maps, the emergence of long-range cortical connections, heightened experience-dependent plasticity and spontaneous uncoordinated skeletal movement. How these various processes cooperate to allow the somatosensory system to form a three-dimensional representation of the body is not known. In the visual system, interactions between spontaneous network patterns and afferent activity have been suggested to be vital for normal development. Although several intrinsic cortical patterns of correlated neuronal activity have been described in developing somatosensory cortex in vitro, the in vivo patterns in the critical developmental period and the influence of physiological sensory inputs on these patterns remain unknown. We report here that in the intact somatosensory cortex of the newborn rat in vivo, spatially confined spindle bursts represent the first and only organized network pattern. The localized spindles are selectively triggered in a somatotopic manner by spontaneous muscle twitches, motor patterns analogous to human fetal movements. We suggest that the interaction between movement-triggered sensory feedback signals and self-organized spindle oscillations shapes the formation of cortical connections required for sensorimotor coordination. |
| Databáze: | OpenAIRE |
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