Prenatal exposure of rare earth elements cerium and ytterbium and neonatal thyroid stimulating hormone levels: Findings from a birth cohort study
| Autor: | Shunqing Xu, Lulin Wang, Senbei Yang, Yuanyuan Li, Aifen Zhou, Lina Zhang, Yunyun Liu, Bingqing Liu, Wei Xia, Lulu Song, Youjie Wang, Zhongqiang Cao, Chao Xiong, Jianing Bi, Mingyang Wu |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male China medicine.medical_specialty 010504 meteorology & atmospheric sciences Urinary system Rare earth Thyrotropin Physiology 010501 environmental sciences 01 natural sciences Cohort Studies chemistry.chemical_compound Thyroid-stimulating hormone Pregnancy Epidemiology medicine Humans Endocrine system Ytterbium Prenatal exposure lcsh:Environmental sciences 0105 earth and related environmental sciences General Environmental Science lcsh:GE1-350 Creatinine business.industry Infant Newborn Cerium medicine.disease chemistry Prenatal Exposure Delayed Effects Female business |
| Zdroj: | Environment International, Vol 133, Iss, Pp-(2019) |
| ISSN: | 0160-4120 |
| DOI: | 10.1016/j.envint.2019.105222 |
| Popis: | Background: Prior studies have suggested exposure to heavy metals and endocrine disrupting chemicals could disturb the homeostasis of thyroid stimulating hormone (TSH), but no epidemiology study concerning the influence of rare earth elements (REE) exposure during pregnancy on neonatal TSH levels. The present study aimed to investigate the relationships between prenatal REE exposure and neonatal TSH levels. Methods: A total of 7367 pregnant women were recruited from Wuhan Children’s Hospital between September 2012 and October 2014 in Wuhan, China. Urinary concentrations of cerium (Ce), and ytterbium (Yb) were measured by inductively coupled plasma mass spectrometry (ICP-MS). Immunofluorescence assay was used to detect neonatal TSH levels. The associations between REE exposure and neonatal TSH levels were evaluated using multivariate linear regression models. Results: The geometric means of maternal urinary Ce and Yb concentrations were 0.060 μg/g creatinine and 0.025 μg/g creatinine, respectively. The results showed that per doubling of maternal urinary Ce and Yb were associated with 4.07% (95% CI: −5.80%, −2.31%), 5.13% (95% CI: −6.93%, −3.30%) decreased neonatal TSH levels respectively in the adjusted model. Sex stratified analysis demonstrated that the decreased neonatal TSH levels were observed both in male infants and female infants, and the decrease was greater in male infants in urinary Ce. There were no significant interactions between maternal urinary Ce, Yb and infant sex (Ce: P for interaction = 0.173, Yb: P for interaction = 0.967). Conclusions: Our findings demonstrated that increased maternal urinary Ce and Yb were associated with decreased neonatal TSH levels. Further researches from different populations are warranted to verify the association and to explore the mechanisms. Keywords: Rare earth elements, Thyroid-stimulating hormone, Newborns, Pregnancy |
| Databáze: | OpenAIRE |
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