Mechanism of action of phenethylbiguanide (phenformin) in man. III. Interrelationship between ethanol and phenethylbiguanide (PBG) in normal and diabetic subjects
| Autor: | Pedro A.L. Fioratti, Alfredo Halpern, Augusto Amaral Silveira, Cesar Fp, A. C. Lerario, Bernardo Léo Wajchenberg, C. E. Leme |
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| Rok vydání: | 1976 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Blood sugar Fatty Acids Nonesterified Phenformin Hypoglycemia chemistry.chemical_compound Endocrinology Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Insulin Obesity Ethanol business.industry Middle Aged medicine.disease Mechanism of action chemistry Basal (medicine) Female medicine.symptom business |
| Zdroj: | Metabolism. 25:957-971 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(76)90125-6 |
| Popis: | A standard 4-hr ethanol infusion (236 mg/min) after a 3-day fast with and without phenformin (25 mg q.i.d.), with blood drawn every hour for 8 hr, was performed on five normal subjects, eight obese nondiabetics, seven obese chemical diabetics, and four nonobese diabetics. Control infusion induced in all subjects a decline in blood sugar levels during and/or after the alcohol challenge, with a parallel decrease in basal plasma insulin. Hypoglycemia and the decrease in insulin secretion were associated with increased plasma free fatty acid concentration. Addition of phenethylbiguanide (PBG) to the preparatory 3-day fast resulted in a greater drop in the blood glucose levels of the normal control subjects, obese and nonobese diabetics; in the obese nondiabetics, however, significantly lower degree of blood glucose decrease than control was elicited. Furthermore, obese nondiabetics altered their blood glucose-insulin interaction with apparent increased responsivess of the B cells of PBG. The results suggest that effects of phenformin on blood glucose levels are more dependent on the metabolic state of the patient than on a property of the drug itself. |
| Databáze: | OpenAIRE |
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