Light chain cast nephropathy caused by plasmablastic lymphoma of the bladder
| Autor: | Vivette D. D'Agati, Mehrian Jafarizade, Sharon Maynard, Krupa Daniel, Kiran Goli, Essel Dulaimi, Bradley Lash |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pathology medicine.medical_treatment Interstitial nephritis education Case Report lymphoma chemical and pharmacologic phenomena plasmablastic lymphoma Organ transplantation Nephropathy medicine medicine.diagnostic_test business.industry Acute kidney injury HIV hemic and immune systems Immunosuppression medicine.disease Lymphoma acute kidney injury bladder lymphoma Nephrology Renal biopsy light chain cast nephropathy Geriatrics and Gerontology interstitial nephritis business Plasmablastic lymphoma |
| Zdroj: | Clinical Nephrology. Case Studies |
| ISSN: | 2196-5293 |
| Popis: | Introduction: Plasmablastic lymphoma (PBL) is a rare form of B-cell lymphoma typically seen in patients with underlying immunosuppression such as HIV, autoimmune disease, and organ transplantation. PBL in HIV-positive patients usually originates from the gastrointestinal tract, with a predilection for the oral cavity. Bladder involvement by PBL is exceedingly rare, and cast nephropathy due to κ light chain-secreting PBL has not been reported previously. Case report: We report a patient who presented with acute kidney injury (AKI) in the setting of HIV, and was found to have a bladder tumor. Bladder pathology revealed a high-grade PBL with κ light chain restriction. Renal biopsy showed κ light chain cast nephropathy, presumably secondary to κ light chain-secreting PBL. Conclusion: Although the prognosis of PBL is poor, our patient recovered from AKI, achieved complete hematologic remission with chemotherapy, and underwent successful autologous stem cell transplant. |
| Databáze: | OpenAIRE |
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