Dual intra-arterial vasodilators in the management of post-aneurysmal subarachnoid haemorrhage vasospasm
| Autor: | Behzad Eftekhar, Joga Chaganti, Richard Waugh, Hannah Woodford, Michael Taylor |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
RD1-811 business.industry Intra-arterial calcium channel blockers Vasodilation Vasospasm medicine.disease Internal medicine Cardiology Intra arterial cardiovascular system Medicine Subarachnoid haemorrhage Cerebral vasospasm Surgery Neurology (clinical) cardiovascular diseases Neurology. Diseases of the nervous system business RC346-429 aSAH |
| Zdroj: | Interdisciplinary Neurosurgery, Vol 27, Iss, Pp 101442-(2022) |
| ISSN: | 2214-7519 |
| Popis: | Objective: Endovascular chemical angioplasty has been in practice in patients with symptomatic cerebral vasospasm secondary to aneurysmal subarachnoid haemorrhage in many neurosurgical centres. However, the evidence base is derived from clinical case series and expert consensus. The aim of this retrospective cohort study is to evaluate the immediate and functional outcomes of endovascular intervention in aneurysmal subarachnoid haemorrhage cerebral vasospasm treated with a combination of vasodilators. Methods: A cohort of 25 patients was identified. Each patient underwent surgical clipping, and endovascular treatment for vasospasm. A combination of Verapamil and Nimodipine was intra-arterially administered. Statistical analysis was performed to determine the rate of response. The angiographic response and functional outcome on discharge (modified Rankin score - MRS) were used as markers of outcome. Results: The study cohort consisted of 25 patients with a mean age of 50.3 (SD 11.2). A total of 135 therapeutic DSA’s were performed. There was an associated between MRS outcomes and number of vasodilation’s each patient received. For each additional vasodilation episode, the odds of a poor outcome increased by 1.190. An angiographic response was demonstrated in 88% of patients, a clinical response in 27%. A good functional outcome was achieved in 17/25, 71% at discharge. Conclusion: The combination therapy of Intra-arterial nimodipine and verapamil in patients with aneurysmal subarachnoid haemorrhage vasospasm appears to have a synergistic, if not comparable, outcome to from solitary vasodilatory treatment results and potentially promote future studies with prospective designs to measure the outcomes. |
| Databáze: | OpenAIRE |
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