Mast cell infiltration in the wall of varicose veins
| Autor: | Danica Pavlíková, Weismann P, Peter Mráz, Peter Kováč, Zora Haviarová, Viera Štvrtinová, Štefan Durdík |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Histology Cell Count Tryptase Varicose Veins chemistry.chemical_compound Varicose veins Image Processing Computer-Assisted medicine Humans Saphenous Vein Mast Cells Tolonium Chloride Coloring Agents Varix Staining and Labeling biology Cell growth business.industry Cell Biology General Medicine Middle Aged Mast cell medicine.disease medicine.anatomical_structure chemistry biology.protein Female medicine.symptom Varices business Infiltration (medical) Histamine |
| Zdroj: | Acta Histochemica. 104:357-360 |
| ISSN: | 0065-1281 |
| Popis: | Summary Varicose veins of the lower extremities are abnormally dilated, tortuous and elongated. The exact cause of vein dilatation has still not been established. Mast cells produce, store and release various types of vasoactive compounds (histamine, tryptase, prostaglandins, leukotrienes, and cytokines). Histamine enhances local vasopermeability and smooth muscle cell proliferation, leading to thickening of the intima. Tryptase can contribute to local vascular injury and subsequent weakness of the vascular wall causing varix formation. The aim of the present study was the comparison of mast cell infiltration in the wall of varicose and non-varicose veins. The mean mast cell density in the wall of varicose veins was 0.86 mast cell per mm2 and in healthy non-dilated vein walls, density was 1.23 mast cell per mm2. This difference was not statistically significant, therefore we could not confirm our hypothesis. Nevertheless, we suggest that mast cells could play an important role in the development of varices and the factor released by the mast cells should be further examined. |
| Databáze: | OpenAIRE |
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