Exogenous factors in the immunotoxicity of oral PMN
| Autor: | Ruggiero Fumarulo, Maria A. Mariggiò, Amalia Cassano |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Time Factors
Drug-Related Side Effects and Adverse Reactions Gingival crevice Neutrophils Immunology Apoptosis Granulocyte Biology Toxicology Dental plaque Periodontal disease medicine Immunology and Allergy Animals Humans Periodontal Diseases Pharmacology Dose-Response Relationship Drug Smoking General Medicine medicine.disease Antimicrobial Chemotaxis Leukocyte medicine.anatomical_structure Pharmaceutical Preparations Toxicity Cell Migration Inhibition |
| Zdroj: | Immunopharmacology and immunotoxicology. 33(1) |
| ISSN: | 1532-2513 |
| Popis: | Current evidence indicates that periodontal disease is frequently due to inappropriate levels of gingival granulocyte functions. Reason of this failure may be the toxic effects of a number of local or systemic exogenous factors, capable of spreading through the gingival crevice environment, and strongly conditioning the granulocyte activities. The wide list includes bacteria and granulotoxic products, hedonistic drugs (mainly tobacco), and chemotherapeutic agents (especially antimicrobials used for preventing or reducing the accumulation of dental plaque). Almost always, their presence induces a time- and/or dose-dependent toxicity. |
| Databáze: | OpenAIRE |
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