Dissection of glucocorticoid receptor-mediated inhibition of the hypothalamic–pituitary–adrenal axis by gene targeting in mice
| Autor: | Lisa M. Muglia, Louis J. Muglia, Gloria Laryea, Melinda G. Arnett |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Hypothalamo-Hypophyseal System
endocrine system medicine.medical_specialty Hypothalamus Pituitary-Adrenal System Adrenocorticotropic hormone Biology Article Mice chemistry.chemical_compound Corticotropin-releasing hormone Receptors Glucocorticoid Glucocorticoid receptor Stress Physiological Corticosterone Internal medicine medicine Animals Endocrine and Autonomic Systems medicine.anatomical_structure Glucocorticoid secretion Endocrinology chemistry Gene Targeting hormones hormone substitutes and hormone antagonists Glucocorticoid Hypothalamic–pituitary–adrenal axis medicine.drug |
| Zdroj: | Frontiers in Neuroendocrinology. 36:150-164 |
| ISSN: | 0091-3022 |
| DOI: | 10.1016/j.yfrne.2014.09.002 |
| Popis: | Negative feedback regulation of glucocorticoid (GC) synthesis and secretion occurs through the function of glucocorticoid receptor (GR) at sites in the hypothalamic-pituitary-adrenal (HPA) axis, as well as in brain regions such as the hippocampus, prefrontal cortex, and sympathetic nervous system. This function of GRs in negative feedback coordinates basal glucocorticoid secretion and stress-induced increases in secretion that integrate GC production with the magnitude and duration of the stressor. This review describes the effects of GR loss along major sites of negative feedback including the entire brain, the paraventricular nucleus of the hypothalamus (PVN), and the pituitary. In genetic mouse models, we evaluate circadian regulation of the HPA axis, stress-stimulated neuroendocrine response and behavioral activity, as well as the integrated response of organism metabolism. Our analysis provides information on contributions of region-specific GR-mediated negative feedback to provide insight in understanding HPA axis dysregulation and the pathogenesis of psychiatric and metabolic disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect