Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women

Autor: Margaret C. Wardle, Elisa Pabon, Heather E. Webber, Harriet de Wit
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Psychopharmacology
ISSN: 1432-2072
0033-3158
Popis: Background The use of cannabis has been clinically associated with decreased motivation to engage in normally rewarding activities. However, evidence from previous controlled studies is mixed. Method In this study, we examined the effects of acute delta-9-tetrahydrocannabinol (THC) versus placebo on a task measuring willingness to exert effort for rewards. This is a secondary analysis of a larger study examining interactions between ovarian hormones and THC. In this within-subjects study, oral THC and placebo were administered under double-blind conditions in counterbalanced order to healthy young adult (M age = 24 years) women with previous cannabis experience who were not regular users. Forty subjects completed three 4-h sessions with PL, 7.5 and 15 mg THC, while an additional 18 completed only PL and 15 mg THC sessions (design abridged due to pandemic). At each session, they completed a task consisting of making repeated choices between a hard and an easy task, which were worth varying amounts of money at varying probabilities. Results THC dose-dependently decreased hard task choices (drug effect, b = − 0.79, SE = 0.29, z = − 2.67, p
Databáze: OpenAIRE
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