Regulating the regulators: the role of nicotinic acetylcholine receptors in human epilepsy
| Autor: | Bertrand D, Hogg Rc |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Pharmacology
Epilepsy Frontal Lobe Xenopus Autosomal dominant nocturnal frontal lobe epilepsy General Medicine Biology Receptors Nicotinic medicine.disease Cell biology Nicotinic acetylcholine receptor Nicotinic agonist Ganglion type nicotinic receptor Drug Discovery Muscarinic acetylcholine receptor M5 Muscarinic acetylcholine receptor Genes Regulator Mutation medicine Oocytes Animals Humans Alpha-4 beta-2 nicotinic receptor Acetylcholine receptor Genes Dominant |
| Zdroj: | Drug newsperspectives. 16(5) |
| ISSN: | 0214-0934 |
| Popis: | Recent advances in genetic mapping have linked several epilepsies to mutations in genes coding for ion channel proteins. Mutations in genes coding for the alpha(4) and beta(2) subunits of the nicotinic acetylcholine receptor have been found in some families suffering from autosomal dominant nocturnal frontal lobe epilepsy. Expression of mutant alleles in the Xenopus oocyte expression system has allowed functional characterization of these mutant receptors at the cellular level. The challenge is now to design therapeutic strategies based on this knowledge of how receptor function is altered in certain epilepsies. |
| Databáze: | OpenAIRE |
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