Reproductive hormones in relation to polycyclic aromatic hydrocarbon (PAH) metabolites among non-occupational exposure of males
| Autor: | Yankai Xia, Shanlei Qiao, Guangbo Fu, Yan Han, Xinru Wang, Pengfei Zhu, Ling Song, Nianzu Jin, Rencheng Zhao, Shoulin Wang |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male China medicine.medical_specialty Environmental Engineering Metabolite Urinary system Naphthols Urine Follicle-stimulating hormone chemistry.chemical_compound Blood serum Reference Values Internal medicine medicine Humans Environmental Chemistry Testosterone Polycyclic Aromatic Hydrocarbons Waste Management and Disposal Fluorenes Pyrenes Estradiol Chemistry Environmental Exposure Luteinizing Hormone Pollution Hormones Prolactin Endocrinology Follicle Stimulating Hormone Human Environmental Monitoring Hormone |
| Zdroj: | Science of The Total Environment. 408:768-773 |
| ISSN: | 0048-9697 |
| DOI: | 10.1016/j.scitotenv.2009.11.021 |
| Popis: | A limited number of studies have suggested that exposure to PAHs may affect reproductive hormones. Subjects (n=642) in this study were from the affiliated hospitals of Nanjing Medical University. Individual exposures to PAHs were measured as spot urinary concentrations of four PAH metabolites, including 1-naphthol (1-N), 2-naphthol (2-N), 2-hydroxyfluorene (2-OF) and 1-hydroxypyrene (1-OP), which were adjusted by urinary creatinine (CR). Blood samples were collected to measure serum levels of reproductive hormones, including follicle-stimulating hormone (FSH), luteotrophic hormone (LH), estradiol (E2), testosterone (T) and prolactin (PRL). All of the subjects had detectable levels of the four metabolites of PAHs in their urine samples. The median concentrations of 1-N, 2-N, 2-OF and 1-OP were 2.440, 4.176, 2.843 and 1.148 microg/g of CR. There were significant P-values between increased CR-adjusted 1-N tertiles and E2 concentration, 2-OF tertiles and LH, FSH level, 1-OP and E2 level. The multivariate linear regression results also showed significant correlation between the levels of serum LH and 1-OP (the adjusting P-value was 0.048), but no correlations were found between other hormones and the level of PAH metabolites. These observed correlations between levels of hydroxy-PAH and some altered hormones indicated slight endocrine effects on adult men with PAH exposure. |
| Databáze: | OpenAIRE |
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