The Relationship Between Serum Interleukin-1α and Asymptomatic Infrarenal Abdominal Aortic Aneurysm Size, Morphology, and Growth Rates
| Autor: | G. Ed Rainger, Andrew W. Bradbury, Rajiv K. Vohra, Gerard B. Nash, James Hodson, Mehtab Ahmad, Sahithi J. Kuravi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Aortography Computed Tomography Angiography macromolecular substances 030204 cardiovascular system & hematology Asymptomatic Gastroenterology 03 medical and health sciences 0302 clinical medicine Aneurysm Interleukin-1alpha Internal medicine medicine Humans Clinical significance Aorta Abdominal cardiovascular diseases Thrombus Aged Ultrasonography Computed tomography angiography Aged 80 and over medicine.diagnostic_test business.industry Interleukin medicine.disease Abdominal aortic aneurysm Asymptomatic Diseases Disease Progression cardiovascular system Female Surgery medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers 030217 neurology & neurosurgery Aortic Aneurysm Abdominal Dilatation Pathologic |
| Zdroj: | European Journal of Vascular and Endovascular Surgery. 56:130-135 |
| ISSN: | 1078-5884 |
| Popis: | OBJECTIVE/BACKGROUND In a pilot study, a relationship between abdominal aortic aneurysm (AAA) diameter and serum interleukin (IL)-1α levels was reported, and that endothelial cell (EC) activation in vitro in response to serum from patients with AAA was blocked by anti-IL-1α antibodies. The aim of the present study was to further investigate the relationship between serum IL-1α and asymptomatic infrarenal AAA size, morphology, and growth rates. METHODS Serum IL-1α was measured using enzyme linked immunosorbent assay in 101 patients with asymptomatic, infrarenal AAA and related to aneurysm size, morphology, and growth rates. RESULTS IL-1α was measured in 101 patients. There was no statistically significant difference in mean age between men and women. IL-1α was detectable in 62.4% of patients; median IL-1α titre was 3.26 pg/mL. There was no statistically significant relationship between IL-1α and maximum AAA antero-posterior diameter as measured by ultrasound (p = .649), AAA morphology (aortic length [p = .394], sac [p = .369], and thrombus volume [p = .629]) as measured on computed tomography, absolute increase in AAA diameter (p = .214), or AAA growth rate (p = .230). CONCLUSION IL-1α is detectable in the majority of patients with infrarenal AAA, but the cause and clinical significance of this novel observation remains unknown. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect