Immune Cell and Adipose Gene Expression Reprogramming in Juvenile Monkeys Born to Health and Weight-Diverse Mothers

Autor: Ruggiero, Alistaire, Block, Masha, Vemuri, Ravichandra, DeStephanis, Darla, Das, Swapan, Kavanagh, Kylie
Rok vydání: 2021
Předmět:
Zdroj: Innovation in Aging
ISSN: 2399-5300
DOI: 10.1093/geroni/igab046.2545
Popis: Over 93 million Americans are obese and 66 million suffer from metabolic disease. Roughly 40% of obese people do not have metabolic abnormalities (metabolically health obese [MHO]), while approximately 15% of lean do (metabolically unhealthy lean [MUL]). African green monkeys (AGMs) demonstrate naturally occurring obesity and metabolic syndrome (MetS) without diet manipulation, and MetS criteria are heritable. Age-matched maternal AGMs were classified by adjusted MetS criteria ([n=44]; waist >40cm, fasting glucose (FG) >100 mg/dL, SBP/DBP >135/85mmHg, and HDL-c
Databáze: OpenAIRE