Hypercalcaemia with disseminated osteolytic lesions: a rare presentation of childhood acute lymphoblastic leukaemia
| Autor: | Shruti Prem, Rajitha Lokadasan, Sumod Mathew Koshy, A. V. Jayasudha |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Cancer Research
Pathology medicine.medical_specialty Hypercalcaemia acute lymphoblastic leukaemia medicine.diagnostic_test business.industry Skeletal survey Research hypercalcaemia medicine.disease osteolytic bone lesions Bone marrow examination Zoledronic acid Oncology hemic and lymphatic diseases medicine Lymphoblastic leukaemia Stem cell Presentation (obstetrics) business medicine.drug Pre b all |
| Zdroj: | ecancermedicalscience |
| ISSN: | 1754-6605 |
| DOI: | 10.3332/ecancer.2015.542 |
| Popis: | Acute lymphoblastic leukaemia (ALL) presenting with hypercalcaemia and lytic bone lesions is a rare event in children unlike adults. We report a 15-year-old boy with acute lymphoblastic leukaemia and hypercalcaemia. He had normal peripheral blood count and the peripheral smear did not show blast. The bone marrow examination revealed Pre B ALL phenotype with aberrant expression of CD13. The skeletal survey showed osteolytic lesions. Hypercalcaemia was treated with zoledronic acid. He attained remission only after three lines of intensive chemotherapy protocols. He was planned for stem cell transplant. Meanwhile, he relapsed and died. A review of the literature also highlights characteristics similar to our case. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|