A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19
| Autor: | Akan Yaman, Handan Bezirganoglu, Resat Gurpinar, Omer Erdeve, Asli Memisoglu, Senol Bozdag, Selahattin Akar, Serdar Cömert, Esin Koç, Emel Ataoglu, Ramazan Ozdemir, Sema Arayici, Handan Hakyemez Toptan, Mustafa Ali Akin, Nihat Demir, Fatma Narter, Leyla Bilgin, Mehmet Yekta Oncel, Cüneyt Tayman, Emrah Can, Timucin Imdadoglu, Emine Esin Yalinbas, Ilke Mungan Akin, Ebru Yalin Imamoglu, Ibrahim Caner, Saime Sundus Uygun, Demet Orhan Baser, Mehmet Kenan Kanburoglu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Turkey medicine.medical_treatment Pneumonia Viral Hypoxemia Betacoronavirus 03 medical and health sciences 0302 clinical medicine Risk Factors 030225 pediatrics Intensive care medicine Humans Prospective Studies Pediatrics Perinatology and Child Health 030212 general & internal medicine Prospective cohort study Pandemics Mechanical ventilation Prothrombin time Pregnancy medicine.diagnostic_test SARS-CoV-2 business.industry Infant Newborn COVID-19 medicine.disease Community-Acquired Infections Hospitalization Oxygen C-Reactive Protein Infectious Diseases Pediatrics Perinatology and Child Health Ambulatory Prothrombin Time Female medicine.symptom Coronavirus Infections business Cohort study |
| Zdroj: | Pediatric Infectious Disease Journal |
| Popis: | BACKGROUND: Coronavirus disease 2019 (COVID-19) primarily affects adults and spares children, whereas very little is known about neonates. We tried to define the clinical characteristics, risk factors, laboratory, and imagining results of neonates with community-acquired COVID-19. METHODS: This prospective multicentered cohort study included 24 neonatal intensive care units around Turkey, wherein outpatient neonates with COVID-19 were registered in an online national database. Full-term and premature neonates diagnosed with COVID-19 were included in the study, whether hospitalized or followed up as ambulatory patients. Neonates without severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) via reverse transcriptase-polymerase chain reaction testing or whose mothers had been diagnosed with COVID-19 during pregnancy were excluded. RESULTS: Thirty-seven symptomatic neonates were included. The most frequent findings were fever, hypoxemia, and cough (49%, 41%, 27%, respectively). Oxygen administration (41%) and noninvasive ventilation (16%) were frequently required; however, mechanical ventilation (3%) was rarely needed. Median hospitalization was 11 days (1-35 days). One patient with Down syndrome and congenital cardiovascular disorders died in the study period. C-reactive protein (CRP) and prothrombin time (PT) levels were found to be higher in patients who needed supplemental oxygen (0.9 [0.1-8.6] vs. 5.8 [0.3-69.2] p = 0.002, 11.9 [10.1-17.2] vs. 15.2 [11.7-18.0] p = 0.01, respectively) or who were severe/critical (1.0 [0.01-8.6] vs. 4.5 [0.1-69.2] p = 0.01, 11.7 [10.1-13.9] vs. 15.0 [11.7-18.0] p = 0.001, respectively). CONCLUSIONS: Symptomatic neonates with COVID-19 had high rates of respiratory support requirements. High CRP levels or a greater PT should alert the physician to more severe disease. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|