Controlling the morphology of copolymeric vectors for next generation nanomedicine
| Autor: | Roxane Ridolfo, Jan C. M. van Hest, David S. Williams, Imke A. B. Pijpers |
|---|---|
| Přispěvatelé: | Bio-Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Polymers
media_common.quotation_subject Pharmaceutical Science Nanotechnology Morphology (biology) 02 engineering and technology Integrated approach 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences Drug Delivery Systems Nanomedicine Drug Design Drug delivery Nanovectors Animals Nanoparticles Biochemical engineering 0210 nano-technology Function (engineering) media_common |
| Zdroj: | Journal of Controlled Release Journal of Controlled Release, 259(10 august 2016), 29-39. Elsevier |
| ISSN: | 0168-3659 |
| Popis: | Amidst the wealth of information that the past few decades of nanomedical research has given us there is one design principle that has emerged as being key for the success of delivery vectors: particle morphology. This review seeks to unpack the various facets of particlemorphology that are important for effective integration in vivo. In order to understand the contribution of morphology towards the biophysical function of nanovectors it is important to consider the historical development of such systems and how their physicochemical characteristics are selected. Ultimately, the purpose of this review is to give a clear perspective for the development of future nanovectors and how an integrated approach to their design, with particular focus upon their morphological features (size, shape, stimuli-responsiveness and surface chemistry), is vital for their performance in vitro and in vivo. (C) 2017 Published by Elsevier B.V. |
| Databáze: | OpenAIRE |
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