Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues

Autor: Sylvie Devaux, Alain Berthelot, R.P. Cosson, Renaud Scheifler, Lysiane Richert, Hélène Martin, F. Hispard, Pierre-Marie Badot, A. de Vaufleury
Přispěvatelé: Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Unité sous contrat biologie environnementale, Institut National de la Recherche Agronomique (INRA)-Université de Franche-Comté (UFC), Optimisation Métabolique et Cellulaire, Université de Franche-Comté (UFC), Mer, molécules et santé EA 2160 (MMS), Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques, Université de Nantes (UN)-Université de Nantes (UN)-Le Mans Université (UM)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire de Biologie Marine, Université de Nantes (UN)-ISOMer, ADEME (Agence De l'Environnement et de la Maîtrise de l'Energie, contract n° 0175037 and 0572 C0058), ANR-05-ECCO-0004,STARTT,Biodisponibilité, transferts et effets des éléments trace métalliques dans des réseaux trophiques terrestres : changements d'échelle spatiale et de niveau d'organisation biologique(2005), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ), Institut National de la Recherche Agronomique ( INRA ) -Université de Franche-Comté ( UFC ), Université de Franche-Comté ( UFC ), Mer, molécules et santé ( MMS ), Université de Nantes ( UN ), Université de Nantes ( UN ) -ISOMer, programme STARTT, ANR-05-ECC0-004,programme STARTT, ANR-05-ECC0-004, Laboratoire Chrono-environnement - UFC (UMR 6249) (LCE), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Le Mans Université (UM)-Université de Nantes - UFR des Sciences Pharmaceutiques et Biologiques
Jazyk: angličtina
Rok vydání: 2008
Předmět:
MESH : Alanine Transaminase
Snails
Wistar
Small
01 natural sciences
MESH: Lipid Peroxidation
Lipid peroxidation
MESH: gamma-Glutamyltransferase
Malondialdehyde
Metallothionein
MESH: Animals
MESH: Snails
MESH : Cadmium
MESH : Environmental Pollutants
chemistry.chemical_classification
0303 health sciences
Cadmium
MESH : Intestine
Small
Glutathione peroxidase
General Medicine
gamma-Glutamyltransferase
Pollution
MESH : Food Chain
Intestine
MESH: Environmental Pollutants
[SDV.TOX.ECO]Life Sciences [q-bio]/Toxicology/Ecotoxicology
medicine.medical_specialty
Food Chain
MESH : Glutathione Peroxidase
MESH : Aspartate Aminotransferases
03 medical and health sciences
MESH: Aspartate Aminotransferases
MESH: Catalase
Aspartate Aminotransferases
Rats
Wistar
Myocardium
MESH: Metallothionein
Public Health
Environmental and Occupational Health
Kidney metabolism
MESH : Metallothionein
Endocrinology
chemistry
MESH : Snails
MESH: Glutathione Peroxidase
Lipid Peroxidation
MESH: Female
Biomarkers
MESH: Liver
MESH: Intestine
Small
Health
Toxicology and Mutagenesis
[ SDV.TOX.ECO ] Life Sciences [q-bio]/Toxicology/Ecotoxicology
010501 environmental sciences
Kidney
chemistry.chemical_compound
Intestine
Small
MESH: Caspase 3
MESH : Myocardium
MESH : Caspase 3
MESH : Female
Gamma-glutamyltransferase
biology
MESH : Lipid Peroxidation
MESH : Rats
Caspase 3
Alanine Transaminase
Catalase
MESH : Kidney
Biochemistry
Liver
Biological Markers
Environmental Pollutants
Female
MESH: Myocardium
MESH: Rats
MESH: Malondialdehyde
MESH: Cadmium
chemistry.chemical_element
MESH : Rats
Wistar
MESH : Catalase
Internal medicine
medicine
Animals
MESH: Food Chain
030304 developmental biology
0105 earth and related environmental sciences
MESH : Malondialdehyde
Glutathione Peroxidase
MESH: Biological Markers
MESH : Liver
MESH: Kidney
MESH: Rats
Wistar
Rats
MESH : Biological Markers
MESH: Alanine Transaminase
biology.protein
MESH : Animals
MESH : gamma-Glutamyltransferase
Zdroj: Ecotoxicology and Environmental Safety
Ecotoxicology and Environmental Safety, Elsevier, 2008, 70 (3), pp.490-8. ⟨10.1016/j.ecoenv.2007.04.005⟩
Ecotoxicology and Environmental Safety, Elsevier, 2008, 70 (3), pp.490-8. 〈10.1016/j.ecoenv.2007.04.005〉
ISSN: 0147-6513
1090-2414
DOI: 10.1016/j.ecoenv.2007.04.005⟩
Popis: International audience; In an experimental food chain, Wistar rats were fed cadmium (Cd) in an inorganic (CdCl(2)) or organic (mainly associated with metallothionein from Helix aspersa snail viscera) form. After 1 month of exposure to 100 microg inorganic Cd g(-1) in food, an induction of metallothionein was observed in all target tissues. In liver, glutathione peroxidase (GSH-Px) activity decreased and alanine aminotransferase (ALAT) activity increased, suggesting that Cd causes hepatotoxicity. However, lipid peroxidation as well as catalase and caspase 3 (a marker of apoptosis) activities were not modified. At a rather low exposure (2.5 microg Cd g(-1)), metallothionein level in the kidney was found to be the most sensitive biomarker of exposure for both Cd forms. In the small intestine of rats ingesting inorganic Cd, metallothionein expression was significantly higher than that observed for rats fed organic Cd. Present results allowed proposing a simple design to assess the effect of a chemical in a trophic transfer approach.
Databáze: OpenAIRE
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