DMAP as a new efficient catalyst for the one-pot synthesis of condensed phthalazines
| Autor: | Abdelmalek Bouraiou, Zouhair Bouaziz, Sofiane Bouacida, Aissa Chibani, Esma Lamera, Hocine Merazig, Marc Le Borgne |
|---|---|
| Přispěvatelé: | Université Mentouri Constantine [Algérie] (UMC), Unité de Recherche de Chimie de l'Environnement et Moléculaire Structurale (CHEMS), Département de Chimie, Molécules bioactives et chimie médicinale (B2MC), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Lab Phys Mat Lamellaires & Nanomat Hybrides (PMLNM), Université de Carthage - University of Carthage, Laboratoire des produits naturels d'origine végétal et de synthèse organique (PHYSYNOR) |
| Rok vydání: | 2017 |
| Předmět: |
[CHIM.ORGA]Chemical Sciences/Organic chemistry
010405 organic chemistry One-pot synthesis [CHIM.THER]Chemical Sciences/Medicinal Chemistry General Chemistry 010402 general chemistry 01 natural sciences 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry [CHIM.CRIS]Chemical Sciences/Cristallography Organic chemistry Phthalazine Efficient catalyst ComputingMilieux_MISCELLANEOUS Phthalazines |
| Zdroj: | Zeitschrift fur Naturforschung B Zeitschrift fur Naturforschung B, Verlag der Zeitschrift Fuer Naturforschung, 2017, 72 ((5)b), pp.361-368. ⟨10.1515/znb-2016-0262⟩ |
| ISSN: | 1865-7117 0932-0776 |
| DOI: | 10.1515/znb-2016-0262 |
| Popis: | A new, convenient, and efficient method for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones is developed starting from phthalhydrazide, aromatic aldehydes, and malononitrile using 4-N,N-dimethylaminopyridin as catalyst. This modified route provides much higher yields and a simple work-up procedure of products. Also this methodology is of interest due to the use of ethanol as a solvent without use of any toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|