Decreased bone density, elevated serum osteoprotegerin, and beta-cross-laps in Wilson disease
| Autor: | Péter Lakatos, Dalma Hegedus, Viktória Ferencz, Cs. Horvath, P. Lakatos, Szilvia Mészáros, Ferenc Szalay |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty Bone disease Bone density Adolescent Endocrinology Diabetes and Metabolism Osteoporosis Osteocalcin Receptors Cytoplasmic and Nuclear Receptors Tumor Necrosis Factor Bone remodeling Osteoprotegerin Hepatolenticular Degeneration Osteoclast Bone Density Internal medicine medicine Humans Orthopedics and Sports Medicine Bone Resorption Aged Glycoproteins Ultrasonography Bone mineral Membrane Glycoproteins biology Receptor Activator of Nuclear Factor-kappa B business.industry RANK Ligand Middle Aged medicine.disease Peptide Fragments Enzymes Endocrinology medicine.anatomical_structure Liver Case-Control Studies biology.protein Female Collagen business Carrier Proteins Densitometry |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 0884-0431 |
| Popis: | Osteopathia has been reported in Wilson disease (WD), but bone density has not been measured; therefore, we performed bone mineral density (BMD), bone mineral content (BMC), and quantitative bone ultrasound (QUS) assessments, as well as measured the serum levels of osteocalcin (OCN), beta-cross-laps (beta-CTx's), and the recently discovered osteoprotegerin (OPG) and its ligand RANKL to investigate the underlying mechanism of osseous disorders. Serum OCN, beta-CTx, OPG, and RANKL levels were measured by ELISA in 21 WD patients and in 20 age- and gender-matched healthy subjects. BMD, BMC, and QUS parameters were also determined. Osteoporosis was present in 9/21 (43%) WD patients. Abnormal QUS parameters were found in 7 (33%) of the patients. Although serum OCN levels were similar in patients and controls (29.93 +/- 24.65 mg/ml vs. 29.84 +/- 6.89 mg/ml), beta-CTx and OPG levels were significantly increased in WD compared with the healthy controls (625.4 +/- 312.3 pg/ml vs. 423.6 +/- 144.3 pg/ml and p = 0.022 and 7.2 +/- 3.4 pM vs. 3.5 +/- 1.0 pM and p0.001, respectively). No difference was observed in the RANKL level. There was a positive correlation between OCN and beta-CTx (r = 0.55; p = 0.01). We proved high occurrence of osteoporosis in WD. Negative bone remodeling balance is a consequence of increased bone resorption, which is indicated by elevated beta-CTx. The novel finding of elevated serum OPG may reflect a compensatory reaction to enhanced osteoclast activity, despite the normal OCN level. |
| Databáze: | OpenAIRE |
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