Pro-neurogenic effect of β-asarone on RSC96 Schwann cells in vitro
| Autor: | Li Zheng, Fuben Xu, Jinmin Zhao, Peizhen Lv, Kun Zhang, Huayu Wu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Cell Survival Neurogenesis Schwann cell Allylbenzene Derivatives Anisoles Biology Pharmacology Cell Line 03 medical and health sciences 0302 clinical medicine Peripheral Nerve Injuries medicine Glial cell line-derived neurotrophic factor Animals Cytotoxic T cell Ciliary Neurotrophic Factor Glial Cell Line-Derived Neurotrophic Factor Viability assay Cell Proliferation Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor Cell Biology General Medicine Nerve Regeneration Rats Neuroprotective Agents 030104 developmental biology medicine.anatomical_structure Cell culture Immunology Peripheral nerve injury biology.protein Schwann Cells Stem cell 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | In Vitro Cellular & Developmental Biology - Animal. 52:278-286 |
| ISSN: | 1543-706X 1071-2690 |
| DOI: | 10.1007/s11626-015-9980-1 |
| Popis: | Nerve regeneration is a challenge for the therapy of peripheral nerve injury. β-Asarone, a major compound extracted from Acorus tatarinowii Schott rhizome, has been traditionally used in China and other parts of Asia for the treatment of common psychiatric diseases. It has been reported to have significant pharmacological effects on the central nervous system. This suggested that β-asarone may be a promising anti-neuroinflammatory and neuroprotective agent to relieve destruction and accelerate proliferation of Schwann cells after peripheral nerve injury. In this study, we investigated the effects of β-asarone on RSC96 Schwann cells, a spontaneously immortalized rat Schwann cell line in vitro. RSC96 cells were treated with a range of β-asarone concentrations (0-90 μM) for 2, 4, and 6 days. Results showed that β-asarone at concentrations down to 22.5 μM were not cytotoxic to RSC96 cells (p |
| Databáze: | OpenAIRE |
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