A Novel Method for Accurate Quantification of Split Glomerular Filtration Rate Using Combination of Tc-99m-DTPA Renal Dynamic Imaging and Its Plasma Clearance
| Autor: | Cheng'en Wang, Xinchen Tao, Zihao Hu, Chang Wenrui, Tao Zhang, Shan Huang, Xiaoxi Pang, Hao Cheng, Fei Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Medicine (General) Article Subject Concordance Tc 99m dtpa Dynamic imaging Clinical Biochemistry 030232 urology & nephrology Renal function Hydronephrosis 030230 surgery urologic and male genital diseases Kidney Consistency test 03 medical and health sciences R5-920 0302 clinical medicine Consistency (statistics) Genetics medicine Humans Molecular Biology Mathematics Aged Tomography Emission-Computed Single-Photon Plasma clearance business.industry Biochemistry (medical) General Medicine Middle Aged medicine.anatomical_structure Technetium Tc 99m Pentetate Female Radiopharmaceuticals Nuclear medicine business Research Article Glomerular Filtration Rate |
| Zdroj: | Disease Markers Disease Markers, Vol 2021 (2021) |
| ISSN: | 1875-8630 0278-0240 |
| Popis: | Purpose. To precisely quantify split glomerular filtration rate by Tc-99m-DTPA renal dynamic imaging and plasma clearance in order to increase its consistency among doctors. Methods. Tc-99m-DTPA renal dynamic imaging was performed according to the conventional radionuclide renal dynamic imaging by five double-blinded doctors independently and automatically calculated split GFR, namely, gGFR. Moreover, the conventional radionuclide renal dynamic imaging was assessed to only outline the kidney, blank background, and automatically calculated split GFR, gGFR ′ . The total GFR value of patients, tGFR, was obtained by the double-plasma method. According to the formula, Precise GFR pGFR = gGF R ′ / gGF R ′ + gGF R ′ × tGFR . The precise GFR value of the divided kidney, pGFR, was calculated. The Kendall’s W test was used to compare the consistency of gGFR and pGFR drawn by five physicians. Results. According to Kendall’s W consistency test, Kendall’s coefficient of concordance was 0.834, p = 0.0001 using conventional method. The same five doctors used blank background again and the same standard Gates method to draw the kidneys, which automatically calculated gGFR ′ . Using input formula, the pGFR was calculated and Kendall’s W consistency test ( Kendal l ’ s coefficient of concordance = 0.956 , p = 0.0001 ). Conclusion. The combination of Tc-99m-DTPA renal dynamic imaging combined with the double-plasma method could achieve accurate split GFR, and because of the omission of influence factors, the consistency of pGFR obtained by different doctors using this method was significantly higher than that of conventional Tc-99m-DTPA renal dynamic imaging. |
| Databáze: | OpenAIRE |
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