Imaging of PDE2- and PDE3-Mediated cGMP-to-cAMP Cross-Talk in Cardiomyocytes
| Autor: | Viacheslav O. Nikolaev, Nikoleta Pavlaki |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adenosine monophosphate lcsh:Diseases of the circulatory (Cardiovascular) system Phosphodiesterase 3 Review 03 medical and health sciences Cyclic nucleotide chemistry.chemical_compound Live cell imaging cAMP Guanosine monophosphate Pharmacology (medical) Nucleotide General Pharmacology Toxicology and Pharmaceutics chemistry.chemical_classification Phosphodiesterase imaging Cell biology cGMP 030104 developmental biology chemistry lcsh:RC666-701 Second messenger system FRET cross-talk phosphodiesterase |
| Zdroj: | Journal of Cardiovascular Development and Disease Journal of Cardiovascular Development and Disease, Vol 5, Iss 1, p 4 (2018) |
| ISSN: | 2308-3425 |
| Popis: | Cyclic nucleotides 3′,5′-cyclic adenosine monophosphate (cAMP) and 3′,5′-cyclic guanosine monophosphate (cGMP) are important second messengers that regulate cardiovascular function and disease by acting in discrete subcellular microdomains. Signaling compartmentation at these locations is often regulated by phosphodiesterases (PDEs). Some PDEs are also involved in the cross-talk between the two second messengers. The purpose of this review is to summarize and highlight recent findings about the role of PDE2 and PDE3 in cardiomyocyte cyclic nucleotide compartmentation and visualization of this process using live cell imaging techniques. |
| Databáze: | OpenAIRE |
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