FreeStyle Libre and Dexcom G4 Platinum sensors: Accuracy comparisons during two weeks of home use and use during experimentally induced glucose excursions
| Autor: | Angelo Avogaro, Valeria Vallone, Anna Maria Letizia Amato, Federico Boscari, M. C. Marescotti, Silvia Galasso, Andrea Facchinetti, Daniela Bruttomesso |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Time Factors Fingerstick Endocrinology Diabetes and Metabolism Medicine (miscellaneous) 030209 endocrinology & metabolism 03 medical and health sciences Young Adult Flash glucose monitoring 0302 clinical medicine Bolus (medicine) Predictive Value of Tests medicine Humans Hypoglycemic Agents Insulin 030212 general & internal medicine Prospective Studies Trial registration Accuracy Continuous glucose monitoring (CGM) Type 1 diabetes Nutrition and Dietetics business.industry Blood Glucose Self-Monitoring Significant difference Reproducibility of Results Equipment Design Home use Middle Aged medicine.disease Hypoglycemia Rate of change Surgery Diabetes Mellitus Type 1 Treatment Outcome Italy Anesthesia Hypoglycaemia Female Cardiology and Cardiovascular Medicine business Biomarkers |
| ISSN: | 0273-4745 |
| Popis: | Background and aims This study compared the accuracy of the FreeStyle Libre (Abbott, Alameda, CA) and Dexcom G4 Platinum (DG4P, Dexcom, San Diego, CA) CGM sensors. Methods and results Twenty-two adults with type 1 diabetes wore the two sensors simultaneously for 2 weeks. Libre was used according to manufacturer-specified lifetime (MSL); DG4P was used 7 days beyond MSL. At a clinical research center (CRC), subjects were randomized to receive the same breakfast with standard insulin bolus (standard) or a delayed and increased (delayed & increased) bolus to induce large glucose swings during weeks 1 and 2; venous glucose was checked every 5–15 min for 6 h. Subjects performed ≥4 reference fingersticks/day at home. Accuracy was assessed by differences in mean absolute relative difference (%MARD) in glucose levels compared with fingerstick test (home use) and YSI reference (CRC). During home-stay the Libre MARD was 13.7 ± 3.6% and the DG4P MARD 12.9 ± 2.5% (difference not significant [NS]). With both systems MARD increased during hypoglycaemia and decreased during hyperglycaemia, without significant difference between sensors. In the euglycaemic range MARD was smaller with DG4P [12.0 ± 2.4% vs 14.0 ± 3.6%, p = 0.026]. MARD increased in both sensors following delayed & increased vs. standard bolus (Libre: 14.9 ± 5.5% vs. 10.9 ± 4.1%, p = 0.008; DG4P: 18.1 ± 8.1% vs. 13.1 ± 4.6%, p = 0.026); between-sensor differences were not significant (p = 0.062). Libre was more accurate during moderate and rapid glucose changes. Conclusions DG4P and Libre performed similarly up to 7 days beyond DG4P MSL. Both sensors performed less well during hypoglycaemia but Libre was more accurate during glucose swings. Trial registration The study was registered in ClinicalTrials.gov ( NCT02734745 ) April 12, 2016. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|