Inverse correlation between serum irisin and cardiovascular risk factors among Chinese overweight/obese population
| Autor: | Yi Li, Kun Tang, Shujing Xu, Ying Hu, Qiao Zhang, Lixin Shi, Xi He, Nianchun Peng, Zhengyi Chen, Ruoyi Liu, Miao Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
China medicine.medical_specialty Irisin Population Overweight Risk Assessment Diabetes mellitus Internal medicine Myokine medicine Humans Diseases of the circulatory (Cardiovascular) system Obesity Risk factor education Aged Dyslipidemias Angiology education.field_of_study business.industry Research Smoking Middle Aged medicine.disease Cardiovascular disease Fibronectins Cross-Sectional Studies Endocrinology Dyslipidemia Cardiovascular Diseases Heart Disease Risk Factors RC666-701 Hypertension Female medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-8 (2021) BMC Cardiovascular Disorders |
| ISSN: | 1471-2261 |
| Popis: | Background Irisin is a novel myokine associated with obesity, which is a traditional cardiovascular risk factor (CVRF). The present study aimed to investigate the association between serum irisin and a single CVRF as well as the clustering of CVRFs among Chinese overweight/obese population. Methods A total of 98 overweight and 93 obese subjects without clinical treatments were enrolled in this study. Subjects were then divided into two groups, based on the serum irisin level: a low irisin group (1.10–13.44 ng/ml) and a high irisin group (13.49–29.9 ng/ml). The clustering of CVRFs, smoking, diabetes mellitus, dyslipidemia and hypertension, was classified as 0, 1, 2 and ≥ 3 CVRFs. The demographic and baseline clinical characteristics of all participants were collected and serum irisin was measured. Results The high serum irisin group had significantly higher high-density lipoprotein cholesterol but lower fasting plasma glucose than the low serum irisin group. Additionally, the high serum irisin group had a significantly lower prevalence of smoking, diabetes mellitus and dyslipidemia than the low serum irisin group. Increased serum irisin was significantly associated with a reduced risk of smoking and dyslipidemia in both the unadjusted and adjusted models. Furthermore, high serum irisin significantly reduced the risk of the prevalence of 1, 2 and ≥ 3 CVRFs. Conclusions among the Chinese overweight/obese populations, high serum irisin is negatively associated with smoking, dyslipidemia and the clustering of CVRFs. Thus, high serum irisin is potentially associated with a low risk of cardiovascular diseases in the Chinese overweight/obese population. |
| Databáze: | OpenAIRE |
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