Melatonin profiles during the third trimester of pregnancy and health status in the offspring among day and night workers: A case series
| Autor: | I. França-Junior, José Leopoldo Ferreira Antunes, Debra J. Skene, Fernanda Gaspar do Amaral, Benita Middleton, Patrícia Nehme, José Cipolla-Neto, Arne Lowden, Elaine Cristina Marqueze, Claudia Roberta de Castro Moreno |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine medicine.medical_specialty Offspring Shift work Maternal Physiology Article lcsh:RC321-571 Melatonin 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Pregnancy medicine RITMOS BIOLÓGICOS EM HUMANOS Circadian rhythm Metabolic disturbances lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry lcsh:QH301-705.5 Premature birth business.industry Obstetrics medicine.disease 030104 developmental biology Neurology lcsh:Biology (General) Breastfeeding difficulties Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neurobiology of Sleep and Circadian Rhythms Neurobiology of Sleep and Circadian Rhythms, Vol 6, Iss, Pp 70-76 (2019) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 2451-9944 |
| Popis: | Successful pregnancy requires adaptation in maternal physiology. During intrauterine life the mother's circadian timing system supports successful birth and postnatal development. Maternal melatonin is important to transmit circadian timing and day length to the fetus. This study aims to describe the third trimester of pregnancy among day (n = 5) and night (n = 3) workers by assessing their melatonin levels in a natural environment. Additionally, we describe the worker's metabolic profiles and compare the health status of the newborns between groups of day and night working mothers. Our results indicate an occurrence of assisted delivery (cesarean and forceps) among night workers. Moreover, the newborns of night workers showed lower Apgar index and breastfeeding difficulty indicating a worse condition to deal with the immediate outside the womb environment. Additionally, there was lower night-time melatonin production among pregnant night workers compared to day workers. These findings may be related to light-induced suppression of melatonin that occurs during night work. We conclude that night work and consequent exposure to light at unconventional times might compromise the success of pregnancy and the health of the newborn. Further studies need to be carried out to monitor pregnancy and newborn health in pregnant night workers. Graphical abstract Image 1 Highlights • There was lower night-time melatonin production among pregnant night workers compared to day workers. • Night work might compromise the success of pregnancy. • Night work during pregnancy might compromise the health of the newborn. |
| Databáze: | OpenAIRE |
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