Analysis of dibenzothiophene metabolic pathway in Mycobacterium strain G3

Autor:	Kenji Maruhashi, Tadaatsu Nakahara, Nobuhiko Nomura, Hideki Okada
Rok vydání:	2002
Předmět:	biology Stereochemistry Metabolite Substrate (chemistry) Bioengineering Metabolism biology.organism_classification Applied Microbiology and Biotechnology chemistry.chemical_compound Metabolic pathway chemistry Dibenzothiophene Thiophene Bacteria Biotechnology Mycobacterium
Zdroj:	Journal of Bioscience and Bioengineering. 93:491-497
ISSN:	1389-1723
Popis:	The dibenzothiophene (DBT) metabolic pathway in Mycobacterium strain G3, which is classified as a desulfurizing microorganism with the 4S pathway, was analyzed. 2-Hydroxybiphenyl (HBP), which is an end metabolite in the DBT desulfurization reaction, and 2-methoxybiphenyl (MBP) were found in the reaction mixture, and the methoxylation pathway from HBP to MBP was clarified. Although the substrate in the methoxylation reaction was HBP, there was no relationship between expression of the methoxylation activity and that of the desulfurization activity. Then, 4,6-dimethyl DBT, 4,6-diethyl DBT and benzo[b]naphtho[2,1-d]thiophene were metabolized to their methoxy forms via the desulfurization pathway. We established the methoxylation pathway in Mycobacterium G3.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d3b3a38e14069fb63bda0cf395ff99 https://doi.org/10.1016/s1389-1723(02)80097-4 Zobrazit plný text záznamu Full Text from ScienceDirect