Prognostic impact of initial tumor load and intraperitoneal disease dissemination patterns in patients with advanced ovarian cancer undergoing complete cytoreductive surgery
| Autor: | Fabrice Lecuru, Charlotte Ngo, Léa Rossi, Myriam Delomenie, Bastien Rance, Anne-Sophie Bats, Jennifer Uzan, Marie Gosset, Eric Pujade-Lauraine, H Bonsang-Kitzis |
|---|---|
| Přispěvatelé: | PRES Sorbonne Paris Cité |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult Male medicine.medical_specialty medicine.medical_treatment [SDV]Life Sciences [q-bio] Population Disease Carcinoma Ovarian Epithelial 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans 030212 general & internal medicine Progression-free survival 10. No inequality education Peritoneal Neoplasms Aged Retrospective Studies Aged 80 and over education.field_of_study Chemotherapy business.industry General Medicine Cytoreduction Surgical Procedures Middle Aged medicine.disease Debulking Prognosis 3. Good health Tumor Burden Survival Rate 030220 oncology & carcinogenesis Conventional PCI Disease Progression Surgery Female Ovarian cancer business Cohort study |
| Zdroj: | EJSO-European Journal of Surgical Oncology EJSO-European Journal of Surgical Oncology, WB Saunders, 2019, 45, pp.1619-1624. ⟨10.1016/j.ejso.2019.04.011⟩ |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2019.04.011⟩ |
| Popis: | Introduction Complete removal of disease is the most important prognostic factor for patients with advanced epithelial ovarian carcinoma. However, the influence of carcinomatosis distribution on prognosis is unknown and the prognostic impact of implant size according to their location is poorly studied. Our objective was to assess the impact of peritoneal carcinomatosis quantitative and qualitative localizations on progression free survival (PFS) in patients with advanced epithelial ovarian carcinoma (AEOC) after complete cytoreductive surgery. Methods We conducted a monocentric cohort study, retrospective from October 2001 to July 2014. Inclusion criteria were high-grade AEOC patients without residual disease (CC0) after primary debulking surgery (PDS) or after interval debulking surgery (IDS) following neoadjuvant chemotherapy (NACT). Peritoneal carcinomatosis was assessed according to qualitative criteria and quantitative criteria. Results One hundred and one patients were included. Median PFS was 21·2 months and median OS was 62·2 months. On the whole population, involvement of adipocytes-enriched areas tended to be associated with a decreased PFS and was significantly associated with a decreased OS. Any localization was associated with PFS or OS in the “IDS” subgroup. In the “PDS” subgroup, PCI score and involvement of the right mesocolic area were associated with a decreased PFS. Conclusion Initial tumor load has not been found associated with PFS after complete surgery. Adipocytes-enriched areas and right mesocolic areas involvement were associated with poor prognosis in patients receiving primary debulking surgery. Larger-scale studies are needed to assess whether initial tumor load has a prognostic impact even after complete cytoreductive surgery is achieved. |
| Databáze: | OpenAIRE |
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