Epstein–Barr Virus Coopts Lipid Rafts to Block the Signaling and Antigen Transport Functions of the BCR
| Autor: | Michelle L. Dykstra, Susan K. Pierce, Richard Longnecker |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Herpesvirus 4
Human B-cell receptor Immunology Receptors Antigen B-Cell Biology Viral Matrix Proteins 03 medical and health sciences Membrane Microdomains 0302 clinical medicine Antigen LYN hemic and lymphatic diseases Tumor Cells Cultured Humans Immunology and Allergy Phosphorylation Antigens Viral Lipid raft 030304 developmental biology Antigen Presentation 0303 health sciences breakpoint cluster region Biological Transport Cross-Linking Reagents src-Family Kinases Infectious Diseases Membrane protein Cancer research lipids (amino acids peptides and proteins) Signal transduction Signal Transduction 030215 immunology |
| Zdroj: | Immunity. 14(1):57-67 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/s1074-7613(01)00089-9 |
| Popis: | The B cell antigen receptor (BCR) functions to initiate signaling and to internalize antigen for processing from within Lyn kinase-enriched membrane lipid rafts. The signaling function of the BCR is blocked by Epstein–Barr Virus (EBV) latent membrane protein 2A (LMP2A), which is constitutively phosphorylated by Lyn. Here, we show that LMP2A resides in lipid rafts and excludes the BCR from entering rafts by Lyndependent mechanisms, thus blocking both BCR signaling and antigen transport. Mutant LMP2A that permits BCR signaling and raft translocation still blocks antigen trafficking, indicating independent control of these BCR functions. Thus, EBV coopts the lipid rafts to disarm both the signaling and antigen-processing functions of the BCR by independent mechanisms. |
| Databáze: | OpenAIRE |
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