3D Gradient and Linearly Aligned Magnetic Microcapsules in Nerve Guidance Conduits with Remotely Spatiotemporally Controlled Release to Enhance Peripheral Nerve Repair

Autor:	Wei-Chen Huang, Chun-Chang Lin, Tzai-Wen Chiu, San-Yuan Chen
Rok vydání:	2022
Předmět:	Polylactic Acid-Polyglycolic Acid Copolymer Delayed-Action Preparations Magnetic Phenomena Nerve Growth Factor Silk Gelatin Capsules Hydrogels General Materials Science Sciatic Nerve Nerve Regeneration
Zdroj:	ACS Applied Materials & Interfaces. 14:46188-46200
ISSN:	1944-8252 1944-8244
DOI:	10.1021/acsami.2c11362
Popis:	Although numerous strategies have been implemented to develop nerve guidance conduits (NGCs) to treat peripheral nerve injury (PNI), functionalization of an NGC to make it remotely controllable for providing spatiotemporal modulation on in situ nerve tissues remains a challenge. In this study, a gelatin/silk (GS) hydrogel was used to develop an NGC based on its self-owned reversible thermoresponsive sol-to-gel phase transformation ability that permitted rapid three-dimensional (3D) micropatterning of the incorporated nerve growth factor (NGF)-loaded magnetic poly(lactic
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24ce67e6ff8b69d1e2c6245079118529 https://doi.org/10.1021/acsami.2c11362 Zobrazit plný text záznamu