White versus gray matter: fMRI hemodynamic responses show similar characteristics, but differ in peak amplitude

Autor: Leanne M. Fraser, Ryan C.N. D'Arcy, Steven D. Beyea, M. Tynan R. Stevens
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
Time Factors
Haemodynamic response
Event-related fMRI
Hemodynamics
Corpus callosum
Brain mapping
Nerve Fibers
Myelinated
Vocabulary
Functional Laterality
030218 nuclear medicine & medical imaging
Corpus Callosum
Functional connectivity
Interhemispheric transfer
0302 clinical medicine
BOLD response
Image Processing
Computer-Assisted
Brain Mapping
medicine.diagnostic_test
General Neuroscience
lcsh:QP351-495
White matter
Brain
Magnetic Resonance Imaging
medicine.anatomical_structure
Cerebral blood flow
Cerebrovascular Circulation
Female
Analysis of variance
Psychology
Research Article
Adult
Transfer
Psychology
lcsh:RC321-571
03 medical and health sciences
Cellular and Molecular Neuroscience
Young Adult
medicine
Humans
lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry
Analysis of Variance
Hemodynamic response function
Magnetic resonance imaging
Oxygen
lcsh:Neurophysiology and neuropsychology
Face
Neuroscience
event-related
030217 neurology & neurosurgery
Photic Stimulation
Zdroj: BMC Neuroscience
BMC Neuroscience, Vol 13, Iss 1, p 91 (2012)
ISSN: 1471-2202
Popis: Background There is growing evidence for the idea of fMRI activation in white matter. In the current study, we compared hemodynamic response functions (HRF) in white matter and gray matter using 4 T fMRI. White matter fMRI activation was elicited in the isthmus of the corpus callosum at both the group and individual levels (using an established interhemispheric transfer task). Callosal HRFs were compared to HRFs from cingulate and parietal activation. Results Examination of the raw HRF revealed similar overall response characteristics. Finite impulse response modeling confirmed that the WM HRF characteristics were comparable to those of the GM HRF, but had significantly decreased peak response amplitudes. Conclusions Overall, the results matched a priori expectations of smaller HRF responses in white matter due to the relative drop in cerebral blood flow (CBF) and cerebral blood volume (CBV). Importantly, the findings demonstrate that despite lower CBF and CBV, white matter fMRI activation remained within detectable ranges at 4 T.
Databáze: OpenAIRE
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