Hancornia speciosa: Indications of gastroprotective, healing and anti-Helicobacter pylori actions
| Autor: | Wagner Villegas, Alba Regina Monteiro Souza Brito, Clenilson Martins Rodrigues, Cláudia Helena Pellizzon, Taís Maria Bauab, Clélia Akiko Hiruma-Lima, Thiago Mello Moraes, Hélio Kushima |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Antioxidant medicine.medical_treatment Bethanechol Pharmacognosy Antioxidants Mice Drug Discovery medicine Gastric mucosa Animals Humans Proanthocyanidins Stomach Ulcer Rats Wistar Pharmacology Gastric Juice Helicobacter pylori Traditional medicine biology Plant Extracts business.industry Hydrogen-Ion Concentration Anti-Ulcer Agents Pylorus biology.organism_classification Mucus Anti-Bacterial Agents Rats Apocynaceae Disease Models Animal medicine.anatomical_structure Gastric Mucosa Plant Bark Medicine Traditional Gastritis medicine.symptom business Brazil medicine.drug |
| Zdroj: | Journal of Ethnopharmacology. 120:161-168 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2008.08.001 |
| Popis: | Ethnopharmacological relevance: Mangaba (Hancornia speciosa Gomez) is a medicinal plant frequently cited in ethnopharmacological inventories of the central region of Brazil against gastrointestinal disorders such as diarrhoea, ulcer, gastritis and stomachache. Aim of the study: The hydroalcoholic extract (HE) and infusion (BI) of Hancornia speciosa bark were investigated for their ability to prevent and heal rodent gastric ulcer. Materials and methods: The preventive and healing action of both preparations of Hancornia speciosa were evaluated in experimental models in rodents that simulated this disease in human gastric mucosa. Results: BI did not exert gastroprotective effect, in contrast to HE (500 mg/kg, p.o.) that decreased (p < 0.05) the severity of gastric damage induced by HCl/ethanol (52%), indomethacin/bethanechol (51%), stress (52%) or pylorus ligature experiments (54%). HE increased (p < 0.05) the pH and decreased acid output of gastric juice. This extract promoted increase of mucus amount (3.62 mg/wt. tissue vs. 5.81 mg/wt. tissue), healing action (67%) and displayed anti-Helicobacter pylori effect. Conclusions: The antiulcer action of Hancornia speciosa resulted in increase of gastric mucus formation and antioxidant properties of polymeric proanthocyanidins present in the bark composition of this medicinal plant. |
| Databáze: | OpenAIRE |
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