Fractionated Dose Effects on Survival and Organ Weights in X-Irradiated Mice
| Autor: | J. G. Kereiakes, A. T. Krebs, W. H. Parr |
|---|---|
| Rok vydání: | 1957 |
| Předmět: |
medicine.medical_specialty
Spleen Fast recovery Biology Nucleic acid metabolism Mice chemistry.chemical_compound Dry weight Physiology (medical) Internal medicine medicine Animals Dose effect Body Weights and Measures Irradiation Radiation business.industry X-Rays Body Weight Organ Size Small intestine medicine.anatomical_structure Endocrinology chemistry Total dose Dose Fractionation Radiation Nuclear medicine business |
| Zdroj: | American Journal of Physiology-Legacy Content. 191:131-134 |
| ISSN: | 0002-9513 |
| DOI: | 10.1152/ajplegacy.1957.191.1.131 |
| Popis: | Intervals between each of five 140-r doses of 1, 3, 5, 7 and 9 hours resulted in survivals of 15, 35, 55, 45 and 40%, respectively, for fractionated total body x-irradiation of mice. A 700-r single dose was 100% lethal. The pattern of the intestinal dry weight response was similar to that for survival. Fractionating the total dose did not seem to significantly alter the 700-r single dose spleen wet weight value. The findings suggest that the fast recovery of the mitotic process and of the nucleic acid metabolism in the small intestine at about 5 hours after irradiation with doses between 100 r and 200 r may be responsible for the observed results for the 5-hour interval fractionated total body x-irradiated mice. |
| Databáze: | OpenAIRE |
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