Pulsed Electromagnetic Fields in Bone Healing: Molecular Pathways and Clinical Applications
Autor: | Valentina Bina, Salvatore Annunziata, Alessandro Ivone, Giulia Gastaldi, Eugenio Jannelli, Gianluigi Pasta, Alice Maria Brancato, Laura Caliogna, Alberto Castelli, Marta Medetti, Mario Mosconi |
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Přispěvatelé: | Caliogna, L., Medetti, M., Bina, V., Brancato, A. M., Castelli, A., Jannelli, E., Ivone, A., Gastaldi, G., Annunziata, S., Mosconi, M., Pasta, G. |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Databases Factual QH301-705.5 Magnetic Field Therapy osteogenic differentiation Bone healing Review Catalysis Inorganic Chemistry 03 medical and health sciences Fractures Bone 0302 clinical medicine Electromagnetic Fields bone regeneration Osteogenesis medicine Humans Medical physics Physical and Theoretical Chemistry Biology (General) Bone regeneration Molecular Biology QD1-999 Spectroscopy pulsed electromagnetic fields (PEMFs) biophysical stimulation Osteogenesi Stem Cells Organic Chemistry General Medicine fracture repair fracture healing Computer Science Applications Clinical trial Clinical Practice Chemistry 030104 developmental biology Electromagnetic Field 030220 oncology & carcinogenesis Human Signal Transduction |
Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 7403, p 7403 (2021) |
ISSN: | 1422-0067 |
Popis: | In this article, we provide an extensive review of the recent literature of the signaling pathways modulated by Pulsed Electromagnetic Fields (PEMFs) and PEMFs clinical application. A review of the literature was performed on two medical electronic databases (PubMed and Embase) from 3 to 5 March 2021. Three authors performed the evaluation of the studies and the data extraction. All studies for this review were selected following these inclusion criteria: studies written in English, studies available in full text and studies published in peer-reviewed journal. Molecular biology, identifying cell membrane receptors and pathways involved in bone healing, and studying PEMFs target of action are giving a solid basis for clinical applications of PEMFs. However, further biology studies and clinical trials with clear and standardized parameters (intensity, frequency, dose, duration, type of coil) are required to clarify the precise dose-response relationship and to understand the real applications in clinical practice of PEMFs. |
Databáze: | OpenAIRE |
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