Decrease in insulin secretion related to hypocalcemia induced by a high dose of zinc in rats
| Autor: | Yamaguchi Masayoshi, Takahashi Kouzi |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Atropine
Male endocrine system medicine.medical_specialty endocrine system diseases Administration Oral chemistry.chemical_element Zinc Toxicology Oral administration Internal medicine Insulin Secretion medicine Animals Insulin Insulin secretion Hypocalcemia nutritional and metabolic diseases Rats Inbred Strains General Medicine Glucose Tolerance Test Rats Endocrinology chemistry Calcium hormones hormone substitutes and hormone antagonists |
| Zdroj: | Toxicology Letters. 22:175-180 |
| ISSN: | 0378-4274 |
| DOI: | 10.1016/0378-4274(84)90063-8 |
| Popis: | A single oral administration of zinc (Zn), sufficient to induce hypocalcemia, caused a decrease in glucose tolerance in fasted rats. This decrease resulted from reduction of insulin secretion. The restoration of Zn-induced hypocalcemia completely prevented the decrease in glucose tolerance and insulin secretion. These results suggest that the effect of Zn administration on insulin secretion in rats is a consequence of hypocalcemia. |
| Databáze: | OpenAIRE |
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