Emerging role of adipokines in systemic lupus erythematosus
| Autor: | Hai-Feng Pan, Dong-Qing Ye, Rui-Xue Leng, Xiao-Mei Li, Hong-Miao Li, Hai-Rong Liu, Xiang-Pei Li, Tian-Ping Zhang |
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| Rok vydání: | 2016 |
| Předmět: |
Leptin
0301 basic medicine Chemokine Immunology Adipokine Adipose tissue Pathogenesis 03 medical and health sciences 0302 clinical medicine Adipokines immune system diseases Animals Humans Lupus Erythematosus Systemic Chemerin Medicine Resistin Molecular Targeted Therapy skin and connective tissue diseases 030203 arthritis & rheumatology biology Adiponectin business.industry nutritional and metabolic diseases 030104 developmental biology Adipose Tissue biology.protein Intercellular Signaling Peptides and Proteins Chemokines business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Immunologic Research. 64:820-830 |
| ISSN: | 1559-0755 0257-277X |
| DOI: | 10.1007/s12026-016-8808-8 |
| Popis: | Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by multisystem organ involvement and unclear pathogenesis. Several adipokines synthesized in the adipose tissue, including leptin, adiponectin, resistin, and chemerin, have been explored in autoimmune rheumatic diseases, especially SLE, and results suggest that these mediators may be implicated in the pathogenesis of SLE. However, the current results are controversial. In this review, we will briefly discuss the expression and possible pathogenic role of several important adipokines, including leptin, adiponectin, resistin, and chemerin in SLE. |
| Databáze: | OpenAIRE |
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