Development and validation of a composite disease activity score for measurement of muscle and skin involvement in juvenile dermatomyositis
| Autor: | Nicolino Ruperto, Angelo Ravelli, Alberto Martini, S Maillard, Anand Prahalad Rao, P. Pratsidou-Gertsi, K. Nistala, Adele Civino, Giulia Camilla Varnier, Jaime de Inocencio, Dragana Lazarevic, Silvia Rosina, Marija Jelušić, Elena Tsitsami, Jelena Vojinovic, Angela Pistorio, Denise Pires Marafon, Francesca Bovis, Pieter Van Dijkhuizen, MM Katsicas, Alessandro Consolaro, Clarissa Pilkington, Balahan Makay, Graciela Espada |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Parents JDM idiopathic inflammatory myositis outcome measures disease activity assessment composite disease activity scores muscle strength assessment paediatric rheumatology medicine.medical_specialty Severity of Illness Index Outcome measures Dermatomyositis JDM Disease activity 03 medical and health sciences 0302 clinical medicine Cronbach's alpha Rheumatology Internal medicine Outcome Assessment Health Care Content validity medicine Humans Pharmacology (medical) Muscle Strength 030212 general & internal medicine Muscle strength assessment Child Juvenile dermatomyositis 030203 arthritis & rheumatology business.industry Reproducibility of Results Construct validity Composite disease activity scores Disease activity assessment medicine.disease idiopathic inflammatory myositis outcome measures disease activity assessment composite disease activity scores muscle strength assessment paediatric rheumatology Idiopathic inflammatory myositis Child Preschool Quality of Life Physical therapy Muscle strength Female Factor Analysis Statistical Inactive disease business Attitude to Health Paediatric rheumatology |
| Zdroj: | Rheumatology (Oxford, England), 58(7), 1196. Oxford University Press |
| ISSN: | 1462-0324 |
| Popis: | OBJECTIVE: To develop a composite DAS for JDM and provide preliminary evidence of its validity. METHODS: The Juvenile DermatoMyositis Activity Index (JDMAI) is composed of four items: physician's global assessment of overall disease activity ; parent's/child's global assessment of child's wellbeing ; measurement of muscle strength ; and assessment of skin disease activity. The score of the JDMAI is the arithmetic sum of the scores of each individual component. Six versions of the JDMAI were tested, which differed in the tools used to assess the third and fourth items. Validation procedures were conducted using three large multinational patient samples including a total of 627 patients. RESULTS: The JDMAI was found to possess face and content validity, good construct validity, satisfactory internal consistency (Cronbach's alpha = 0.58- 0.89), fair responsiveness to clinically important change (standardized response mean = 0.82-3.12 among patients improved) and strong capacity to discriminate patients judged as being in the state of inactive disease or low, moderate or high disease activity by the physician (P < 0.001) or whose parents were satisfied or not satisfied with the course of their child's illness (P < 0.001). Overall, the six versions of the JDMAI showed similar metrological performances in validation analyses. CONCLUSION: The JDMAI was found to possess good measurement properties in a large population of patients with a wide range of disease activity, and is, therefore, suitable for use in both clinical and research settings. The final version of the JDMAI will be selected after its prospective validation |
| Databáze: | OpenAIRE |
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