Metabolite structure analysis by high-resolution MS: supporting drug-development studies
| Autor: | David S. Wagner, Jill L. Pirhalla, Gary D Bowers |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Structure analysis
Chemistry Metabolite Clinical Biochemistry High resolution General Medicine Bioinformatics Mass Spectrometry Analytical Chemistry Terminology Medical Laboratory Technology chemistry.chemical_compound Pharmaceutical Preparations Drug development Animals Humans Biochemical engineering Instrumentation (computer programming) General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Bioanalysis. 5:463-479 |
| ISSN: | 1757-6199 1757-6180 |
| Popis: | Effective characterization of drug metabolites in complex biological matrices is facilitated by mass spectrometers with high resolving power, mass accuracy and sensitivity. This review begins with an overview of high-resolution MS terminology and the different types of instrumentation that are currently available. Metabolite structure analysis offers unique challenges and, therefore, the different types of approaches used to solve problems are highlighted through specific examples. Overall, this review describes the value that high-resolution MS brings to drug-metabolism studies. |
| Databáze: | OpenAIRE |
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