Exercise-induced modulation of cardiac lipid content in healthy lean young men

Autor: Joachim E. Wildberger, Patrick Schrauwen, Hildo J. Lamb, L. Bilet, Vera B. Schrauwen-Hinderling, ME Marianne Eline Kooi, Mkc Matthijs Hesselink, T. van de Weijer, Jan F. C. Glatz
Přispěvatelé: RS: NUTRIM - R1 - Metabolic Syndrome, RS: CARIM School for Cardiovascular Diseases, RS: MHeNs School for Mental Health and Neuroscience, Humane Biologie, Nutrition and Movement Sciences, Moleculaire Genetica, Beeldvorming
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Adult
Male
Cardiac function curve
EXPRESSION
medicine.medical_specialty
Physiology
METABOLISM
DISEASE
Cardiac lipid content
Young Adult
Physiology (medical)
Internal medicine
REPRODUCIBILITY
Magnetic resonance spectroscopy
medicine
Humans
Exercise physiology
Exercise
Plasma (free) fatty acids
ACCUMULATION
chemistry.chemical_classification
RISK
Ejection fraction
Chemistry
Myocardium
Fatty Acids
Cardiac function
Fatty acid
Lipid metabolism
Original Contribution
Metabolism
MAGNETIC-RESONANCE-SPECTROSCOPY
Lipid Metabolism
medicine.disease
Obesity
Endocrinology
Heart failure
OBESITY
cardiovascular system
HEART-FAILURE
Magnetic resonance spectroscopy Cardiac lipid content Cardiac energy status Cardiac function Plasma (free) fatty acids Exercise magnetic-resonance-spectroscopy myocardial triglyceride content heart-failure lipotoxic cardiomyopathy skeletal-muscle human obesity in-vivo reproducibility metabolism accumulation
Energy Metabolism
Cardiology and Cardiovascular Medicine
Oxidation-Reduction
Cardiac energy status
MYOCARDIAL TRIGLYCERIDE CONTENT
Zdroj: Basic Research in Cardiology, 106(2), 307-315
Basic Research in Cardiology, 106(2), 307-315. D. Steinkopff-Verlag
Basic Research in Cardiology, 106(2), 307-315. Springer
Basic Research in Cardiology
ISSN: 0300-8428
Popis: Cardiac lipid accumulation is associated with decreased cardiac function and energy status (PCr/ATP). It has been suggested that elevated plasma fatty acid (FA) concentrations are responsible for the cardiac lipid accumulation. Therefore, the aim of the present study was to investigate if elevating plasma FA concentrations by exercise results in an increased cardiac lipid content, and if this influences cardiac function and energy status. Eleven male subjects (age 25.4 +/- A 1.1 years, BMI 23.6 +/- A 0.8 kg/m(2)) performed a 2-h cycling protocol, once while staying fasted and once while ingesting glucose, to create a state of high versus low plasma FA concentrations, respectively. Cardiac lipid content was measured by proton magnetic resonance spectroscopy (H-1-MRS) at baseline, directly after exercise and again 4 h post-exercise, together with systolic function (by multi-slice cine-MRI) and cardiac energy status (by P-31-MRS). Plasma FA concentrations were increased threefold during exercise and ninefold during recovery in the fasted state compared with the glucose-fed state (p < 0.01). Cardiac lipid content was elevated at the end of the fasted test day (from 0.26 +/- A 0.04 to 0.44 +/- A 0.04%, p = 0.003), while it did not change with glucose supplementation (from 0.32 +/- A 0.03 to 0.26 +/- A 0.05%, p = 0.272). Furthermore, PCr/ATP was decreased by 32% in the high plasma FA state compared with the low FA state (n = 6, p = 0.014). However, in the high FA state, the ejection fraction 4 h post-exercise was higher compared with the low FA state (63 +/- A 2 vs. 59 +/- A 2%, p = 0.018). Elevated plasma FA concentrations, induced by exercise in the fasted state, lead to increased cardiac lipid content, but do not acutely hamper systolic function. Although the lower cardiac energy status is in line with a lipotoxic action of cardiac lipid content, a causal relationship cannot be proven.
Databáze: OpenAIRE
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