Craniofacial surgery for nonmelanoma skin malignancy: report of an international collaborative study
| Autor: | Shin Etsu Kamata, William I. Wei, Paul A. Levine, Carl H. Snyderman, Ashok Polluri, Ellie Maghami, Paul J. Donald, Snehal G. Patel, Sultan A. Pradhan, Patrick G. Bridger, Victor Schramm, Ivo P. Janecka, Bhuvanesh Singh, Luiz Paulo Kowalski, Simon G. Talbot, Geraldo De Sa, Anthony D. Cheesman, Giulio Cantù, Jatin P. Shah, Dennis H. Kraus, Dan M. Fliss, Luiz Roberto Medina dos Santos, Patrick Gullane |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin Neoplasms Adolescent International Cooperation Skull Neoplasms Malignancy Disease-Free Survival Surgical Flaps Postoperative Complications medicine Humans Basal cell carcinoma Neoplasm Invasiveness Craniofacial Child Craniofacial surgery Aged Aged 80 and over business.industry Brain Neoplasms Cancer Histology Middle Aged medicine.disease Surgery Otorhinolaryngology Epidermoid carcinoma Carcinoma Basal Cell Chemotherapy Adjuvant Child Preschool Carcinoma Squamous Cell Female Radiotherapy Adjuvant Skin cancer business Follow-Up Studies |
| Zdroj: | Headneck. 29(12) |
| ISSN: | 1043-3074 |
| Popis: | Background. This study examined the efficacy of craniofacial surgery (CFS) in treating locally advanced nonmelanoma skin cancer (NMSC). Methods. One hundred twenty patients who underwent CFS for NMSC were identified from 17 participating institutions. Patient, tumor, and treatment information was analyzed for prognostic impact on survival. Results. Surgical margins were negative in 74%, close in 3%, and involved in 23% of patients. Complications occurred in 35% of patients, half of which were local wound problems. Operative mortality was 4%. Median follow-up interval after CFS was 27 months. The 5-year overall survival (OS), disease-specific survival (DSS), and recurrence-free survival (RFS) rates were 64%, 75%, and 60%, respectively. Squamous cell histology, brain invasion, and positive resection margins independently predicted worse OS, DSS, and RFS. Conclusion. CFS is an effective treatment for patients with NMSC invading the skull base. Histology, extent of disease, and resection margins are the most significant predictors of outcome. © 2007 Wiley Periodicals, Inc. Head Neck, 2007 |
| Databáze: | OpenAIRE |
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